Diamine oxidase (DAO) is abundantly expressed in mammalian small intestine catalyzing the oxidative breakdown of polyamines and histamine. The aim of this study was to determine the relationship between stimulation of intestinal diamine oxidase secretion with intestinal fat absorption and histamine release. Conscious intestinal lymph fistula rats were used. The mesenteric lymph ducts were cannu...

Acetyl cholinesterase (AchE) and N-methyl-D-aspartate antagonists are at present the only commercially available treatment for Alzheimer's disease (AD). Histamine H3 receptor antagonists are used for the treatment of several neurodegenerative disorders such as Epilepsy, Alzheimer‘s and Parkinson‘s diseases. Both H3 and AchE inhibitors alleviate the symptoms of Alzheimer’s disease by enhancing t...

The aim of the present study was to investigate whether and by which mechanism; histamine can induce state-dependent retrieval of passive avoidance task. The pre-training or pre-test intracerebroventricular (i.c.v.) injection of histamine (20µg/mouse) impaired retrieval, when it was tested 24 h later. In the animals, which retrieval was impaired due to histamine pre-training administration, pre...

It has been well established that cardiac actions of histamine are mediated by histamineHI and H2 receptors and that there exist specific agonists and antagonists acting on them (1.2.3:4.5.7.8 and 11). Cyclizine. an antihistamine has been shown to antagonize positivechronotropic effect of histamine which is mediated through H2 receptors (8) and to possessantiarrhythmic effect in experiernntal c...

Mequitazine [10-(3-quinuclidinylmethyl) phenothiazine] is a long-acting and selective histamine H1-receptor antagonist that is mainly biotransformed by human liver microsomes to yield hydroxylated and S-oxidized metabolites. Mequitazine hydroxylase was inhibited by propranolol and quinidine. Lineweaver-Burk plots for the hydroxylation and the S-oxidation indicated that the hydroxylation occurre...