The ability of histamine to stimulate gastric acid secretion was recognized over 75 years ago by Popielski [1]. The central importance of this action in the physiological regulation of acid secretion was established with the development of histamine H2 receptor antagonists by Black and colleagues in the early 1970s [2]. There has, however, been intense debate about the precise mechanisms of act...

Objective: Crocin and safranal, as the major constituents of saffron, have many biological activities. This study investigated the effects of crocin and safranal on yawning response induced by intracerebroventricular (i.c.v.) injection of histamine in rats. Materials and Methods: In ketamine/xylazine-anesthetized rats, a guide cannula was implanted in the right ventricle of the brain and yawnin...

Agents known to interact with either microtubules or microfilaments influenced the antigen-induced release of histamine from the leukocytes of allergic individuals. Deuterium oxide (D(2)O) which stabilizes microtubules and thereby favors their formation enhanced histamine release markedly. Concentrations as low as 5% increased antigen-induced release somewhat while concentrations as high as 75%...

Cyclic adenosine 3’,5’-monophosphate (cyclic AMP) accumulates in guinea pig cerebral cortical slices during incubations with histamine, histamine-norepinephrine, adenosine, adenosine-histamine, adenosine-norepinephrine, adenosinehistamine-norepinephrine, veratridine, and veratridine-histamine. The rate of increase of cyclic AMP levels in response to various agents appears to be limited to some ...

It has been well established that cardiac actions of histamine are mediated by histamineHI and H2 receptors and that there exist specific agonists and antagonists acting on them (1.2.3:4.5.7.8 and 11). Cyclizine. an antihistamine has been shown to antagonize positivechronotropic effect of histamine which is mediated through H2 receptors (8) and to possessantiarrhythmic effect in experiernntal c...

N alpha-methylhistamine (N alpha-MH) is one of unusual metabolite of histamine that was found in Helicobacter pylori-infected stomach and is believed to interact with specific histamine H1, H2 and H3-receptors to stimulate gastric acid secretion and gastrin release from isolated G-cells but the effects of N alpha-MH on gastric mucosal integrity have been little studied. This study was designed;...

abstract   introduction: inflammation and wear debris may be responsible for bone lysis and subsequent lost in aseptic arthroplasty. prostaglandin e2, platelet activating factor, and histamine are important mediators of inflammatory cells. we studied histopathological changes of cement-bone interface after using specific antagonists of these mediators.   methods: left and right tibiae of 120 ra...

INTRODUCTION The neuroendocrine histamine-secreting cell of the gastric fundus, the enferochromaffin-like cell, is the principal regulator of parietal cell acid secretion. We have proposed that histamine may regulate its own synthesis and release via an autocrine mechanism. The purpose of this study was to evaluate the role of the histamine receptor subtypes H1, H2 and H3 in the regulation of t...

objective: to investigate the effect of intracerebroventricular injection of histamine on pain induced by subcutaneous iniection of formalin in the left ear of rabbit and the effect of the amine on morphine analgesia and naloxone hyperalgesia. design: experimental study. animals: sixty - six male new zealand white rabbits weighing 2.640.16kg. procedure: intracerebroventricular injections of the...