THE DEVELOPMENT of a successful surgical treatment for Hirschsprung's disease 11 and the establishment of a sound pathologic and etiologic basis 3 for the disease have been among the most gratifying events in Pediatric Surgery of the last decade. The result has been to render accurate diagnosis possible with precision. At the same time the knowledge that an effective surgical treatment is avail...

Objective(s) Definite diagnosis of Hirschsprung’s disease (HD) is based on histopathological study, but there are limitations associated with standard histology and histochemistry in this regard. The aim of this study was to investigate calretinin immunostaining patterns in both ganglionic and aganglionic HD intestinal specimens and to compare them with control specimens. Materials and Method...

AIMS AND OBJECTIVES The aim of this study is to find easier way of home care while obviating the colostomy before single stage pull through operation. MATERIALS AND METHODS From August 2005 to December 2006, eight cases of neonatal Hirschsprung disease were treated. Mean age 4.5 (2-6) day/old with absent anorectal inhibitory reflex, rectosigmiod disease in Barium enema, positive Acetylcholine...

Waardenburg syndrome (WS) is a rare disorder characterized by pigmentation defects and sensorineural deafness, classified into four clinical subtypes, WS1-S4. Whereas the absence of additional features characterizes WS2, association with Hirschsprung disease defines WS4. WS is genetically heterogeneous, with six genes already identified, including SOX10. About 50 heterozygous SOX10 mutations ha...