BACKGROUND Parabens are preservatives commonly used in personal care products, pharmaceuticals, and foods. There is documented widespread human exposure to parabens, and some experimental data suggest that they act as estrogenic endocrine disruptors. As far as we are aware, no epidemiologic studies have assessed female reproductive health effects in relation to paraben exposure. OBJECTIVE We ...

BEFORE embarking upon a discussion of anovulatory infertility, it is necessary to define a physiologically normal menstrual cycle and to review our present knowledge of the hormonal changes that occur. In humans a 'normal' cycle has a mean length of 28 32 days+0 6 days (SD = 5 41 days), ovulation occurs and there must be normal corpus luteum function. Recent reviews of the normal changes in the...

As is the case in other tetrapod species, the chicken gonadotropins LH and FSH consist of a common alpha subunit and a hormone-specific beta subunit. Gonadotrophs containing LH were shown earlier to be distributed throughout both the caudal and cephalic lobes of the chicken anterior pituitary, but the cellular distribution of FSH in avian species is still uncertain. The purpose of this study wa...

The role of follicle-stimulating hormone (FSH) in the control of spermatogenesis is not well established in any species, including man. We studied the effect of an experimentally-induced, selective FSH deficiency on sperm production in normal men. After a 3-mo control period, five normal men received testosterone enanthate (T) 200 mg i. m. weekly to suppress luteinizing hormone (LH) and FSH, un...

STUDY QUESTION Is the treatment with recombinant FSH (rFSH) plus recombinant LH (rLH) more effective than highly purified (HP)-hMG in terms of ongoing pregnancy rate (PR) in women ≥35 years of age undergoing intrauterine insemination (IUI) cycles? SUMMARY ANSWER The ongoing PR was not significantly different in women treated with rFSH plus rLH or with HP-hMG. WHAT IS KNOWN ALREADY Although ...

Measurement of the urinary excretion of lutropin (LH) and follitropin (FSH) and their common free alpha subunit (FAS) assists in monitoring the maturation of the hypothalamic-pituitary-gonadal axis and in understanding the physiology of the pituitary glycoprotein hormones. Here we describe sensitive, specific polyclonal radioimmunoassays for LH and FSH and a monoclonal radioimmunoassay for FAS ...

Fucan was first isolated by Kylin from brown seaweed and named fucoidin by him (1). More recently fucan was isolated by Percival and Ross (2) from several Phaeophyceae. They considered it to be a polymeric salt of fucose monosulfate. However, their most highly purified preparation still contained approximately 5.6% sugars other than L-fucose and 3.3 ‘% uranic acid. A branched structure was sugg...