Alcohol dehydrogenation and condensation reactions are involved in chain growth pathways on Cu/MgCeOx promoted with potassium. These pathways lead to the formation of isobutanol with high selectivity via reactions of higher alcohols with methanol-derived C1 species in reaction steps also relevant to higher alcohol synthesis from CO/H2 mixtures at higher pressures on K–Cu/MgCeOx catalysts. Ethan...

The catalytic asymmetric synthesis of tertiary alcohols by the addition of organometallic reagents to ketones is of central importance in organic chemistry. The resulting quaternary stereocentres are difficult to prepare selectively by other means despite their widespread occurrence in natural products and pharmaceuticals. Here we report on a new methodology which allows access to both α-bromo-...

The synthesis of a broad range enantioenriched amines by the direct Fe-catalysed coupling with alcohols through borrowing hydrogen strategy, while at least one these substrates is achiral reported. When starting from α-chiral and alcohols, wide amine products, including N-heterocyclic moieties can be obtained complete retention stereochemistry power this method demonstrated in one-step known ph...

A porous phenolsulphonic acid-formaldehyde resin (PAFR) was developed. The heterogeneous catalyst PAFR was applied to the esterification of carboxylic acids and alcohols, affording the carboxylic acid esters in a yield of up to 95% where water was not removed from the reaction mixture. Surprisingly, the esterification in water as a solvent proceeded to afford the desired esters in high yield. P...

The synthesis of γ-amino alcohols 1 is of great interest due to the pharmacology of these compounds and their derivatives. This functionality is found in several antibiotics and other biologically active natural products. Several synthetic methods have been described for the synthesis of γ-amino alcohols 1 from diols, hydroxazols, lactams and lactones, but the more important methods are those w...

A new method for the direct synthesis of imines from alcohols and amines is described where hydrogen gas is liberated. The reaction is catalyzed by the ruthenium N-heterocyclic carbene complex [RuCl2(IiPr)(p-cymene)] in the presence of the ligand DABCO and molecular sieves. The imination can be applied to a variety of primary alcohols and amines and can be combined with a subsequent addition re...

Aluminum-containing mesoporous silica with hierarchical macroporous architecture (Al-MMS) was successfully prepared using a solvent evaporation method through the combination of precursor solution for synthesis of Al-containing mesoporous silica (Al-MS) and poly(methyl methacrylate) (PMMA) colloidal crystals as a hard template. The porous structure and the state of aluminum were investigated us...

BACKGROUND Fermentative aromas play a key role in the organoleptic profile of young wines. Their production depends both on yeast strain and fermentation conditions. A present-day trend in the wine industry consists in developing new strains with aromatic properties using adaptive evolution approaches. An evolved strain, Affinity™ ECA5, overproducing esters, was recently obtained. In this study...

Logic programs can be synthesized as a by-product of the planning of their verification proofs. This is achieved by using higher-order variables at the proof planning level, which become instantiated in the course of planning. We illustrate two uses of such variables in proof planning for program synthesis, one for synthesis proper and one for the selection of induction schemes. We demonstrate ...