PURPOSE The present study was explored to develop a sustained release matrix tablet of Indapamide, a low-dose thiazide-type diuretic, using hydroxylpropyl methylcellulose (Methocel K15MCR) in various proportions as release controlling factor. METHODS The tablets were formulated using direct compression method. The powers for tableting were evaluated for angle of response, loose bulk density, ...

In this study, attempts were made to evaluate the effect of various acrylic acid based Carbopols on the release profile of a beta-adrenoreceptor blocking drug, propranolol HCl, from matrix-type tablets invitro. For this purpose, tablets containing 160 mg of propranolol HCl along with various amounts of Carbopols 934 (C934), 971 (C971), 974 (C974) and Pemulen (Pem) were prepared using the wet gr...

Darunavir is a nonpeptidic inhibitor of protease and primarily metabolized by cytochrome P450 3A (CYP3A) isoenzymes. It usually coadministered with low-dose ritonavir (Darunavir/r). Ritonavir an CYP3A isoenzymes pharmacologically enhances which leads to increased plasma concentrations darunavir allows for daily lower dose. Here, we have developed combination SR formulation evaluated. In vitro d...

PURPOSE The aim of this study was to formulate stable film-coated montelukast sodium (MS) tablets using Opadry(®) yellow 20A82938 (Montikast(®) tablets) and to evaluate their in vitro and in vivo release profile. METHODS MS core tablets were manufactured using a direct compression method. Opadry yellow 20A82938 aqueous coating dispersion was used as the film-coating material. Dissolution of t...

BACKGROUND Antioxidants, in particular vitamin C, have been suggested to decrease oxidative DNA damage. Such effects have been shown in mononuclear blood cells in the first few hours after ingestion, whereas studies of longer-term effects in well-nourished humans have been mainly negative. AIM To investigate the antioxidant effect of vitamin C in terms of oxidative DNA damage measured by the ...

Chlorzoxazone is a centrally acting muscle relaxant used to treat muscle spasm and the resulting pain and discomfort which are having shorter half life (1.1hour) with the dose administration of 3-4 times a day. The aim of the study was to prepare and evaluate the Chlorzoxazone sustained release tablets in order to reduce the dose frequency and to improve the patient compliance. The tablets were...

The mechanical and disintegration properties of paracetamol tablets formulated using Delonix regia seed gum (DRSG) as a binder have been studied in this work. Acacia BP (ACG) and tragacanth BP (TRG) were used as official gum standards. The mechanical properties, i.e. tensile strength (TS) and brittle fracture index (BFI), showed that with an increase in concentration of the gum binder, the tens...

Sustained release tablets of isoniazid were fabricated using guar gum and carbapol, Tragacanth Gum and PEG-6000, in different proportion and combinations by direct compression technique, Bulk density, tapped density, compressibility index, Hausner ratio before being punched as tablets. The tablets were evaluated for physical characteristic like hardness, weight variation, friability, and drug c...

extended-release matrix tablets of diltiazem hydrochloride (dtz) were prepared using waxy materials alone or in combination with kollidon sr. matrix waxy materials were carnauba wax (cw), bees wax (bw), cetyl alcohol (ca) and glyceryl monostearate (gms). dissolution studies were carried out by using a six stations usp xxii type 1 apparatus. the in vitro drug release study was done in 1000 ml ph...