نتایج جستجو برای: hey2

تعداد نتایج: 190  

2015
Daniela Salat Anja Winkler Henning Urlaub Manfred Gessler Tsutomu Kume

The Hey protein family, comprising Hey1, Hey2 and HeyL in mammals, conveys Notch signals in many cell types. The helix-loop-helix (HLH) domain as well as the Orange domain, mediate homo- and heterodimerization of these transcription factors. Although distinct interaction partners have been identified so far, their physiological relevance for Hey functions is still largely unclear. Using a tande...

2017
Adriana Harbuzariu Antonio Rampoldi Danielle S Daley-Brown Pierre Candelaria Tia L Harmon Crystal C Lipsey Derrick J Beech Alexander Quarshie Gabriela Oprea Ilies Ruben R Gonzalez-Perez

Pancreatic cancer (PC) shows a high death rate. PC incidence and prognosis are affected by obesity, a pandemic characterized by high levels of leptin. Notch is upregulated by leptin in breast cancer. Thus, leptin and Notch crosstalk could influence PC progression. Here we investigated in PC cell lines (BxPC-3, MiaPaCa-2, Panc-1, AsPC-1), derived tumorspheres and xenografts whether a functional ...

2017
Wen-Cheng Chung Junqing Wang Yunyun Zhou Keli Xu

Background Kras mutations and increased Notch activation occur frequently in gallbladder cancer. However, their roles in gallbladder carcinogenesis have not been defined. This study was aimed at determining whether expression of mutant Kras was sufficient to induce gallbladder carcinoma and whether Notch deregulation played a role in this context. Methods We determined Cre recombination activ...

2014
Kazuya Ono Tomoko Kita Shigeru Sato Paul O'Neill Siu-Shan Mak Marie Paschaki Masataka Ito Noriko Gotoh Kiyoshi Kawakami Yoshiki Sasai Raj K. Ladher

Inner ear mechanosensory hair cells transduce sound and balance information. Auditory hair cells emerge from a Sox2-positive sensory patch in the inner ear epithelium, which is progressively restricted during development. This restriction depends on the action of signaling molecules. Fibroblast growth factor (FGF) signalling is important during sensory specification: attenuation of Fgfr1 disrup...

Journal: :European review for medical and pharmacological sciences 2015
Q-D Zhang M-Y Xu X-B Cai Y Qu Z-H Li L-G Lu

OBJECTIVE The development of liver fibrosis has been shown to be associated with the transition of quiescent hepatic stellate cells (HSCs) into myofibroblastic HSCs, and the Notch signaling system has been shown to be activated in this process. The Notch signaling pathway is also known to regulate epithelial-mesenchymal transition (EMT). MATERIALS AND METHODS In the current study, quiescent H...

Journal: :Circulation research 2013
Bas J Boukens Marc Sylva Corrie de Gier-de Vries Carol Ann Remme Connie R Bezzina Vincent M Christoffels Ruben Coronel

RATIONALE In patients with Brugada syndrome, arrhythmias typically originate in the right ventricular outflow tract (RVOT). The RVOT develops from the slowly conducting embryonic outflow tract. OBJECTIVE We hypothesize that this embryonic phenotype is maintained in the fetal and adult RVOT and leads to conduction slowing, especially after sodium current reduction. METHODS AND RESULTS We det...

2015
Khushboo Irshad Saroj Kant Mohapatra Chitrangda Srivastava Harshit Garg Seema Mishra Bhawana Dikshit Chitra Sarkar Deepak Gupta Poodipedi Sarat Chandra Parthaprasad Chattopadhyay Subrata Sinha Kunzang Chosdol

Hypoxia is a hallmark of solid tumors including glioblastoma (GBM). Its synergism with Notch signaling promotes progression in different cancers. However, Notch signaling exhibits pleiotropic roles and the existing literature lacks a comprehensive understanding of its perturbations under hypoxia in GBM with respect to all components of the pathway. We identified the key molecular cluster(s) cha...

Journal: :Journal of neuropathology and experimental neurology 2015
William D Brandt Karisa C Schreck Eli E Bar Isabella Taylor Luigi Marchionni Eric Raabe Charles G Eberhart Fausto J Rodriguez

Pilocytic astrocytoma (PA) is the most common primary brain tumor in children; various signaling pathways have been implicated in its biology. The Notch signaling pathway has been found to play a role in the development, stem cell biology, and pathogenesis of several cancers, but its role in PA has not been investigated. We studied alterations in Notch signaling components in tumor tissue from ...

2008
Aly Karsan Kyle Niessen

The Notch signaling pathway has been demonstrated to play a critical role during mammalian cardiac development based on recent findings from gene-targeted mice. In addition, mutations in the Notch signaling pathway have been associated with human congenital heart defects such as Alagille syndrome, bicuspid aortic valve disease, calcification of the heart valves, and ventricular septal defects. ...

Journal: :Development 2005
Bon-Kyoung Koo Hyoung-Soo Lim Ran Song Mi-Jeong Yoon Ki-Jun Yoon Jin-Sook Moon Young-Woong Kim Min-Chul Kwon Kyeong-Won Yoo Myung-Phil Kong Jinie Lee Ajay B Chitnis Cheol-Hee Kim Young-Yun Kong

The Delta-Notch signaling pathway is an evolutionarily conserved intercellular signaling mechanism essential for cell fate specification. Mind bomb 1 (Mib1) has been identified as a ubiquitin ligase that promotes the endocytosis of Delta. We now report that mice lacking Mib1 die prior to embryonic day 11.5, with pan-Notch defects in somitogenesis, neurogenesis, vasculogenesis and cardiogenesis....

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