نتایج جستجو برای: hey1
تعداد نتایج: 234 فیلتر نتایج به سال:
Abstract Objectives Notch is a conserved pathway involved in cell-fate determination and homeostasis. Its dysregulation plays role poor prognosis drug resistance breast cancer. Targeting signaling via inhibition of the gamma-secretase complex spotlight modern cancer treatments. Gamma-secretase inhibitors (GSI) have shown successful clinical activity treating cancers, yet possible mechanism rema...
BACKGROUND Hairy and enhancer of split 1 (HES1), a basic helix-loop-helix transcriptional repressor, is a downstream target of Notch signaling. Notch signaling and HES1 expression have been linked to growth and survival in a variety of human cancer types and have been associated with increased metastasis and invasiveness in human osteosarcoma cell lines. Osteosarcoma (OSA) is an aggressive canc...
Abstract During the early development, skeletal muscle, adipose, and connective tissues have high plasticity are sensitive to in uterine nutritional fluctuations. past decade, maternal nutrition-induced changes myogenesis adipogenesis during fetal stage been extensively studied their alterations closely associated with production efficiency meat quality of farm animals. Organogenesis initiates ...
RBPjκ-dependent Notch signaling regulates multiple processes during cartilage development, including chondrogenesis, chondrocyte hypertrophy and cartilage matrix catabolism. Select members of the HES- and HEY-families of transcription factors are recognized Notch signaling targets that mediate specific aspects of Notch function during development. However, whether particular HES and HEY factors...
زمینه و هدف: سرطان مری ششمین عامل مرگ در جهان می باشد. با وجود درمان هایی همچون شیمی درمانی، رادیوتراپی و جراحی طول عمر بیماران بعد از شناسایی بسیار کوتاه دارد. از سویی شناسایی، پیشگیری و درمان بموقع نیاز به مشخص کردن مسیرهای مولکولی این نوع سرطان می باشد. در این مطالعه بمنظور مشخص شدن هر چه بیشتر مسیر رشد و نمو( development) با هدف قرار دادن فاکتور رونویسی SOX2 در یکی از رده های سلولی سرطان مر...
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