Rotational power spectrum analysis of scanning transmission electron micrographs of negatively stained herpesvirus capsids has given direct evidence for the 6-fold symmetry of the herpesvirus hexon capsomere. Individual hexons have been analyzed in situ without interference from other parts of the capsid because only one level of the capsid was in focus in the micrograph. This study found hexon...

Responses to bath-applications of 4-aminopyridine(4-AP) and gamma-aminobutyric acid (GABA) were recorded intracellularly from neurones in the rat isolated superior cervical ganglion. 4-aminopyridine (0.1-1.0 mmol/l) usually induced spontaneous action potentials and excitatory postsynaptic potentials (EPSPs), which were blocked by hexamethonium. Membrane potential was unchanged; spike duration w...

Hexamethonium bromide in normotensive and renal hypertensive dogs resulted in significant reductions in arterial blood pressure, cardiac output and cardiac work. Ihe decrease in cardiac output relative to that in blood pressure suggests that the blood pressure reduction was largely due to the decrease in cardiac output. There was a decrease in coronary flow accompanied by an increase in myocard...

IN A PREVIOUS study it was demonstrated that hexamethonium, although a potent anticholihergic compound capable of lowering blood pressure for short periods, is not satisfactory as a single drug for the longterm treatment of severe hypertension.' While this study w-as in progress, preliminary clinical iinvestigationi of hydralazine (Apresoline) demonstrated this compound to be partially effectiv...

OPINIONS differ vastly and there has been considerable controversy about the usefulness and the advisability of using hypotensive drugs as an adjunct to surgery. Let us, therefore, at the outset say that, within our very limited experiences (some 370 cases in all), we have formed a very favourable opinion of their use in anaesthesia for ear, nose and throat surgery. Of the papers published so f...