Group A Streptococcus (GAS) causes a wide range of human infections, ranging from simple pharyngitis to life-threatening necrotizing fasciitis and toxic shock syndrome. A globally disseminated clone of M1T1 GAS has been associated with an increase in severe, invasive GAS infections in recent decades. The secreted GAS pore-forming toxin streptolysin O (SLO), which induces eukaryotic cell lysis i...

The cyclo-octadepsipeptide anthelmintic, emodepside, has pleiotropic effects on the behaviour of the model genetic animal Caenorhabditis elegans: it inhibits locomotion, feeding, egg-laying and slows development. Previous studies on pharyngeal muscle indicated a role for latrophilin-dependent signalling and therefore prompted the suggestion that this is a common effector of this drug's actions....

While a great portion of the scheduling literature focuses on time-based criteria, the most important goal of management is maximizing the profitability of the firm. In this paper, the net preset value criterion is studied taking account of linear time-dependent cash flows in single machine and flow shop scheduling problems. First, a heuristic method is presented for the single machine scheduli...

PURPOSE To assess β-zone peripapillary atrophy (β-PPA) using spectral domain optical coherence tomography (SD-OCT), scanning laser ophthalmoscopy (SLO), and fundus auto-fluorescence (FAF) imaging in patients with primary open-angle glaucoma with advanced glaucomatous visual field defects. METHODS A consecutive, prospective series of 82 study eyes with primary open-angle glaucoma were included...

A design problem of cross-docking distribution networks is addressed as a new research area in logistics management. This paper presents a new mathematical model for the location of cross-docking facilities and vehicle routing scheduling problems in distribution networks. For this purpose, a two-phase mixed-integer programming (MIP) is formulated. Then, a new heuristic-based simulated annealing...

From its position in presynaptic nerve terminals, the large conductance Ca(2+)-activated K+ channel, Slo, regulates neurotransmitter release. Several other ion channels known to control neurotransmitter release have been implicated in physical interactions with the neurotransmitter release machinery. For example, the Ca(v)2.2 (N-type) Ca2+ channel binds to and is modulated by syntaxin-1A and SN...

Symptoms of withdrawal from chronic alcohol use are a driving force for relapse in alcohol dependence. Thus, uncovering molecular targets to lessen their severity is key to breaking the cycle of dependence. Using the nematode Caenorhabditis elegans, we tested whether one highly conserved ethanol target, the large-conductance, calcium-activated potassium channel (known as the BK channel or Slo1)...

in this paper by combining caching and replication techniques proposed a hybrid heuristic method based on the greedy algorithm to use the benefit of each other techniques. the algorithm in each interaction compares all the contents and one that made the best benefit value is selected for replication. the hybrid approach tested in a simulation environment and the results show that hybrid algorit...

periodic vehicle routing problem focuses on establishing a plan of visits to clients over a given time horizon so as to satisfy some service level while optimizing the routes used in each time period. this paper presents a new effective heuristic algorithm based on data mining tools for periodic vehicle routing problem (pvrp). the related results of proposed algorithm are compared with the resu...

Integrated production-distribution planning (PDP) is one of the most important approaches in supply chain networks. We consider a supply chain network (SCN) to consist of multi suppliers, plants, distribution centers (DCs), and retailers. A bi-objective mixed integer linear programming model for integrating production-distribution designed here aim to simultaneously minimize total net costs in ...