herpes simplex virus 1 (hsv-1) unspliced 8.3 latency associated transcript (lat), which located in the long repeat sequences, has been shown to contain at least 16 open reading frames (orf: a-p). one of these orf, orf p, maps almost entirely antisense to hsv-1 neurovirulence gene, icp34.5. both orf p and icp34.5 are located in the long repeat and are antisense overlapping genes. therefore, in o...

Herpes simplex virus-type 1 is among the most prevalent and successful humans pathogens. Although infection is largely uncomplicated in the immunocompetent human host, HSV-1 infection can cause blinding corneal disease, and individuals with defects in innate or adaptive immunity are susceptible to herpes simplex encephalitis. Chemokines regulate leukocyte trafficking to inflamed tissues and pla...

Herpes simplex virus (HSV) is an enveloped double-stranded DNA virus that is a common pathogen in humans. There are 2 subtypes, HSV-1 and HSV-2, which are distinguished by their different DNA composition. Their nucleic acids demonstrate approximately 50% base sequence homology.1 The subtypes also differ in a surface glycoprotein, gG: HSV-1 has gG1 and HSV-2 has gG2; they form the basis of type-...

Stimuli such as u.v. light or trauma which induce recurrence of herpes simplex may act by affecting virus replication in the skin. Such stimuli release pharmacologically active agents in the skin, including prostaglandins (PGs) such as PGE2. These agents, and other compounds which alter levels of adenosine cyclic monophosphate (cyclic AMP), were tested for their effect on the replication of her...

Purpose To report a case of hypertrophic herpes simplex virus (HSV) of the eyelid and cornea masquerading as IgG4-related disease. Observations A 37-year old African American female with a past medical history of human immunodeficiency virus (HIV) on highly active antiretroviral therapy (HAART) and a recent history of treated genital herpes, presented with an ulcerative lesion of the left upp...

This is the guideline for genital herpes simplex virus (HSV) management for the IUSTI/WHO Europe, 2010. They describe the epidemiology, diagnosis, clinical features, treatment and prevention of genital HSV infection. They include details on the management of HSV in pregnancy, those who are immunocompromised and the clinical investigation and management of suspected HSV-resistant disease.

The interferon (IFN) response to viral pathogens is critical for host survival. In humans and mouse models, defects in IFN responses can result in lethal herpes simplex virus 1 (HSV-1) infections, usually from encephalitis. Although rare, HSV-1 can also cause fulminant hepatic failure, which is often fatal. Although herpes simplex encephalitis has been extensively studied, HSV-1 generalized inf...

objective(s) herpes simplex viruses (hsvs) have widespread and ubiquitous prevalence in the human population and they have received a great deal of attention due to the range of diseases, they caused as a result of an infection. it seems that the fast and reliable diagnostic methods are needed for detecting the herpes simplex virus type 1 (hsv1) antibodies especially in patients with hsv enceph...

conclusions herpes simplex virus was present in more patients with ms than healthy cases. hsv may be directly or indirectly associated with ms development. further comprehensive molecular studies are needed to confirm the etiopathologic association between hsv and ms disease. results totally, 63 (76.8%) patients with ms showed a history of hsv exposure by anti-hsv testing compared to 70 (78.7%)...

The presence of Herpes Simplex Virus-type 2 (HSV type 2), Cytomegalovirus(CMV) and Adenovirus lgG antibodies was determined in sera from a total 144 patients with hematologic solid organ malignancies. HSV type-2 were detected using the EIA method antibody levels 34(48.5 %) ofthe 56(75.6 malignancies of90 (62.5 %). Anti-CMV IgG same serum samples complement fixation test. Residual anti-CMV 43(61...