Drs. Levine and Gemignani have provided a comprehensive review of the literature regarding the management of patients with hereditary breast/ovarian cancer syndrome. As noted, over 200,000 new cases of breast cancer and 25,000 new cases of ovarian cancer are estimated for 2003.[1] Only a small portion of these cases will be hereditary; however, these are the cases that may benefit from preventi...

Background A patient's medical history and familial cancer history are important information for assessing the risk of hereditary cancer. We have generated a self-administered questionnaire for patients with gynecologic cancer. This pilot study analyzed the usefulness of this questionnaire and the rates of patients that meet the Society of Gynecologic Oncology criteria in ovarian cancer and end...

Abstract Muir–Torre syndrome is a rare variant of hereditary nonpolyposis colorectal cancer, also known as Lynch syndrome. It caused by defect in mismatch repair genes, which are most commonly inherited an autosomal dominant fashion. characterized clinically sebaceous neoplasms the skin associated with at least one visceral malignancy, colon cancer being frequent. The common genetic defects res...

The American Society of Pediatric Hematology/Oncology (ASPHO) 2012 Annual Meeting included an interactive workshop on the rapidly expanding topic of hereditary cancer syndromes in children. As discussed, the Sword of Damocles is an appropriate analogy to consider when approaching families with extraordinarily high risk for developing cancer [1]. This expression is based on the story of a sword ...

objective: since the identification of the two highly penetrant dominantly inherited genes, brca1/2, in the 1990s, a number of other genes have been identified which account for approximately 25% of the genetic basis for hereditary breast cancer. at least 75% are unidentified. the goal of this study is to investigate the presence or absence of a recessive pattern of inheritance in this heteroge...

normal 0 false false false en-us x-none ar-sa microsoftinternetexplorer4 background : there is a lack of data on familial aggregation of colorectal cancer (crc) in iran. we aimed to determine the frequency of hereditary nonpolyposis colorectal cancer (hnpcc) and familial colorectal cancer (fcc) and to determine the frequency of extracolonic cancers in these families in isfahan. methods : we rev...

Li-Fraumeni syndrome is a rare cancer predisposition syndrome classically associated with remarkably early onset of cancer in families with a typical spectrum of malignancies, including sarcoma, breast cancer, brain tumors, and adrenocortical carcinoma. Because the risks of cancer development are strikingly high for Li-Fraumeni syndrome, aggressive cancer surveillance is often pursued in these ...

Introduction. The aim of the study is to evaluate the incidence and phenotype genotype characteristics of hereditary colorectal cancer syndromes in Latvia in order to develop the basis of clinical management for patients and their relatives affected by these syndromes. Material and methods. From 02/1999-09/2002 in several hospitals in Latvia cancer family histories were collected from 865 patie...