PURPOSE Carcinoma progression is linked to a partially dedifferentiated epithelial cell phenotype. As previously suggested, this regulation could involve transcription factors, Snail and Slug, known to promote epithelial-mesenchymal transitions during development. Here, we investigate the role of Snail and Slug in human breast cancer progression. EXPERIMENTAL DESIGN We analyzed Snail, Slug, a...

Biological changes in Snail-overexpressed SGC7901 cells were studied by establishing a pEGFP-C1-Snail carrier. The significance of Snail in epithelial-mesenchymal transition (EMT) as well as the invasion and metastatic capacity of gastric cancer cells was also discussed; moreover, we attempted to verify the probable cancer stem cell characteristics of Snail-overexpressed cells. A pEGFP-C1-Snail...

Schistosomiasis is a major healthy problem in China, which is one of most badly suffered four countries in the world, and Schistosoma japonicum infection is prevalent in China. In addition, the snail is the only intermediate snail host of Schistosoma japonicum. Therefore, elimination of snail is an important measure that controls and eliminates schistosomiasis. In order to find out the distribu...

This paper reports ongoing investigations into the use and role of paper-mail communications in domestic environments. It utilises ethnographically informed data to analyse how paper mail supports various social roles within the home, particularly a division of labour whereby women tend to be largely responsible for what may be called “managing the home”. Implications for the future of paper ma...

BACKGROUND In ovarian cancer (OC) cells, Snail was reported to induce the epithelial-to-mesenchymal transition (EMT), which is a critical step in OC metastasis. At present little is known about controlling Snail expression in OC cells by using specific microRNAs (miRNAs). METHODS We first used a computational target prediction analysis to identify 6 candidate miRNAs that bind to the 3'-untran...

background: trematodes are a diverse group of endoparasites which require molluscan and vertebrate animals as intermediate and definitive hosts in their life cycle. the present study was carried out to determine the diversity and geographic distribution of infection with trematodes’cercariae in the snail lymnaea gedrosiana from north-west iran. methods: a total number of 6759 lymnaeidae snails ...

Understanding how predators respond to fluctuations in prey density has important conservation andmanagement implications, particularly for threatened and endangered specialists. However, directly linking prey densities to predator behavior and demography over broad spatial and temporal scales is rare, in part, because it can be prohibitively expensive and time-consuming to quantify prey densit...

The transcription factor Snail controls epithelial-mesenchymal transitions (EMT) by repressing E-cadherin expression and other epithelial genes. However, the mechanisms involved in the regulation of Snail function are not fully understood. Here we show that lysyl-oxidase-like 2 and 3 (LOXL2 and LOXL3), two members of the lysyl-oxidase gene family, interact and cooperate with Snail to downregula...

In this study, we explored the roles of Snail and NF-κB in hepatocellular carcinoma (HCC). Samples of HCC tumor tissue were collected from 83 Chinese HCC patients. Snail and NF-κB expression was then examined based on immunohistochemical staining, and the relations between Snail and NF-κB expression and the clinical characteristics of the patients were assessed using Cox model analysis. Snail a...

The recurring decimal of rural and urban poverty in Nigeria, resulting from lack of sustainable livelihood activities by the people due to non-diversification of the economy, necessitated this study. One hundred snail farmers were randomly selected in Akure North and Akure South Local Government areas of Ondo State, Southwest Nigeria where snail farming is widely practised. Data collection was ...