نتایج جستجو برای: hepatosteatosis

تعداد نتایج: 397  

2010
Amrom E. Obstfeld Eiji Sugaru Marie Thearle Anne-Marie Francisco Constance Gayet Henry N. Ginsberg Eleanore V. Ables Anthony W. Ferrante

OBJECTIVE Obesity induces a program of systemic inflammation that is implicated in the development of many of its clinical sequelae. Hepatic inflammation is a feature of obesity-induced liver disease, and our previous studies demonstrated reduced hepatic steatosis in obese mice deficient in the C-C chemokine receptor 2 (CCR2) that regulates myeloid cell recruitment. This suggests that a myeloid...

2016
Kelli A. Lytle Donald B. Jump Hervé Guillou

BACKGROUND Nonalcoholic fatty liver disease (NAFLD) is a major public health burden in western societies. The progressive form of NAFLD, nonalcoholic steatohepatitis (NASH), is characterized by hepatosteatosis, inflammation, oxidative stress, and hepatic damage that can progress to fibrosis and cirrhosis; risk factors for hepatocellular carcinoma. Given the scope of NASH, validating treatment p...

Journal: :F1000Research 2022

Abstract Background: Asparaginases are common chemotherapeutic agents used for the treatment of acute lymphoblastic leukemia as a single or combinational therapy. Accompanying hepatotoxicity makes its use in elderly patients with pre-conditions, obesity other hepatopathies, difficult. Various hepatoprotective compounds like, L-carn...

BACKGROUND: Hepatic steatosis due to estrogen therapyincreases the activity of inflammatory markers, particularly theactivity of TNFα which in turn induces more lipogenesis.Omega-3 fatty acids are among the negative regulators of hepaticlipogenesis. OBJECTIVES: In this research, the preventive effectof omega-3 fatty acids on estrogen-induced steatosis in rats wasevaluated. METHODS:2 mg/kg. BW/S...

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