Noonan’s syndrome is a polymorphic disorder with some facial features, congenital heart defects, cryptorchidism, etc., and also associated autoimmune diseases, lymphatic dysplasias. Here we are reporting nine years old boy Noonan's who has hepatomegaly persistently raised hepatic enzymes, which remained unexplained.
 TAJ 2022; 35: No-1: 137-140

BACKGROUND Patients with advanced myelofibrosis often suffer from symptomatic extramedullary hematopoiesis in spleen and/or liver. In case of drug-refractory disease splenomegaly is treated surgically, whereas hepatomegaly is palliated by radiotherapy (RT). CASE REPORT A 56-year-old man with advanced and drug-refractory myelofibrosis suffered from extensive hepatomegaly with severe upper abdo...

The aim of the present studies was to describe the effect of two organohalogen pesticides: DDT and bromopropylate, on early changes in rat liver, proposed in the literature to be useful endpoints in screening of non-genotoxic hepatocarcinogens and/or liver tumor promoters. We investigated the effects on the following endpoints: hepatomegaly, mitogenesis (DNA synthesis, mitotic activity, percent...

To cite: Timofte I, Potosky D, Ramani GV, et al. BMJ Case Rep Published online: [please include Day Month Year] doi:10.1136/bcr-2014208449 DESCRIPTION A 56-year-old woman with severe pulmonary arterial hypertension (PAH) presented with right upper quadrant abdominal pain. The patient was diagnosed with PAH 5 years prior and started on oral therapy, but due to worsening pulmonary haemodynamics a...

Hepatocellular carcinoma (HCC) is one of the most common cancers and a leading cause of cancer mortality. Prognosis of this disease largely depends on its stage. An Enlarged liver, due to dysplasia, may be a critical point in the multi-step progression to HCC. The mechanism underlying hepatomegaly in human and mouse models are poorly understood. We previously reported we observed enlarged liver...