Hepatocellular carcinoma (HCC) is a common and aggressive cancer with high mortality rate. The incidence of HCC increasing worldwide, the lack effective screening programs often results in delayed diagnosis, making it challenging disease to manage. Immunotherapy has emerged as promising treatment option for different kinds cancers, potential stimulate immune system target cells. However, curren...

Introduction Long non-coding RNA LINC00641 has been reported to regulate tumor progression in several cancers. However, the expression and function of hepatocellular carcinoma (HCC) is still unclear. Material methods In this study, we measured 79 pairs HCC adjacent normal liver tissues. The clinical significance was explored. We also investigated proliferation invasion. Results observed that si...

Pre-mRNA processing factor 19 (Prp19) activates pre-mRNA spliceosome and also mediates DNA damage response. Prp19 overexpression in cells with functional p53 leads to decreased apoptosis and increases cell survival after DNA damage. Here we showed that in hepatocellular carcinoma (HCC) cells with inactive p53 or functional p53, Prp19 was down-regulated due to the impaired stability under chemot...

BACKGROUND Hepatocellular carcinoma (HCC) is one of the most frequent cancers in the world. Calreticulin(CRT) is aberrantly overexpressed in many human cancer cells. The function of CRT in HCC cells remains unclear. We attempted to investigate the effects and the underlying mechanisms of CRT down-regulation on HCC cell growth, apoptosis, cell cycle progression and invasion. METHODS To investi...

AIM To investigate the expression of cysteine-rich61 (Cyr61), connective tissue growth factor (CTGF) and nephroblastoma overexpressed gene (Nov) in hepatocellular carcinoma (HCC), and to evaluate the relationship between Cyr61, CTGF and Nov genes expression with invasion and metastasis of HCC. METHODS Thirty-one HCC specimens were divided into small hepatocellular carcinoma (SHCC), nodular he...

Over the past several decades, entecavir (ETV) and tenofovir disoproxil fumarate (TDF) have remained first-line antiviral agents in international guidelines. These two shown similar short to intermediateterm efficacy, including virologic, biochemical, serologic, histologic responses. However, huge controversies regarding efficacy of ETV TDF preventing development hepatocellular carcinoma (HCC) ...

Liver cancer has a poor prognosis predominantly resulting from tumour heterogeneity and limited treatment options. The two predominant types of liver are Hepatocellular carcinoma (HCC) Intrahepatic Cholangiocarcinoma (iCCA). CD44v6, splice variant the hyaluronic acid receptor CD44, is marker for stem cells, known to impact formation metastasis in several cancers. expression CD44v6 dramatically ...

Experimental hepatocellular carcinoma (HCC) in rats did not take up intravenously administered indocyanine green (ICG) and trypan blue, while surrounding tissue did. The lack of ICG uptake was also observed by peritoneoscopy in patients with HCC. The contrast between ICG-stained cirrhotic nodules and HCC tumors was intensified with infrared photography. Non-uptake of dyes by HCC cells may enabl...

hepatocellular carcinoma (hcc) represents one of the most common neoplasms worldwide.  liver trasnplantation (lt) is the treatment of choice for selected group of patients with hcc. lt is actually a consolidated therapeutic option for hcc because it cures both tumor and underlying cirrhosis. in 1996, the publication of a pivotal prospective study on less than 50 patients, transplanted for hcc u...

Hepatocellular carcinoma (HCC) is one of the most common malignancies worldwide; however, the prognosis of HCC patients remains poor. This poor prognosis is mainly attributed to the high rate of intrahepatic and distant metastasis. HCC often occurs in a hypoxic environment and hypoxia can activate metastatic programs, ultimately leading to tumor r...