background: kinesin spindle protein (ksp) plays a critical role in mitosis. inhibition of ksp function leads to cell cycle arrest at mitosis and ultimately to cell death. the aim of this study was to suppress ksp expression by specific small-interfering rna (sirna) in hep3b cells and evaluate its anti-tumor activity. methods: three sirna targeting ksp (ksp-sirna #1-3) and one mismatched-sirna (...

introduction since directly acting antivirals (daas) for treatment of hepatitis c virus (hcv) were introduced, conflicting data emerged about the risk of hepatocellular carcinoma (hcc) after interferon (ifn)-free treatments. we present a case of recurrent, extra-hepatic hcc in a liver-transplanted patient soon after successful treatment with daas, along with a short review of literature. conclu...

BACKGROUND More than 50% of the worldwide cases of hepatocellular carcinoma occur in China, and this malignancy currently represents the country's second leading cause of cancer death in cities and the leading cause in rural areas. Despite recent advances in the control and management of hepatocellular carcinoma within China, this disease remains a major health care issue. The global HCC BRIDGE...

Hepatoid adenocarcinoma (HAC) is a unique type of extrahepatic that histologically mimics the appearance hepatocellular carcinoma (HCC). stomach has poor prognosis with increased potential for liver metastasis. HCC and HAC share clinicopathological immunohistochemical features. The diagnosis metastatic hepatoid to challenging. It often misdiagnosed as carcinoma. diagnostic dilemma more

BACKGROUND The purpose of this study was to evaluate the potential value of circulating miRNA-122a and miRNA-221 in the diagnosis of hepatocellular carcinoma. METHODS Serum samples were obtained from 85 patients with hepatocellular carcinoma and 85 age-matched and sex-matched healthy volunteers. miRNAs were isolated from the serum samples, and alfa-fetoprotein levels were determined. Expressi...

Randomized clinical trials and actual practice differsignificantly. Evidence-based medicine develops new agents referring to, primarily, pharmaceutical findings, preclinical studies and, most importantly, randomized trials. Hepatocellular carcinoma is the common primary malignancy of liver, one main causes fatal outcomes among cancer patients worldwide, including in Asia-Pacific region, with an...

Hepatocellular carcinoma arises in patients as a consequence of long-standing preexisting liver illnesses, including viral hepatitis, alcohol abuse, or metabolic disease. In such preexisting liver diseases, TGF-β plays an important role in orchestrating a favorable microenvironment for tumor cell growth and promoting epithelial-mesenchymal transition (EMT). TGF-β signaling promotes hepatocellul...

Hepatocellular carcinoma has been identified as the fifth most common cancer in men and the ninth in women worldwide. Despite many efforts have been made in recent years, the overall survival rate of patients with hepatocellular carcinoma still remain unsatisfied. Therefore, exploring the mechanisms underlying the progression of hepatocellular carcinoma is essential for developing novel treatme...

Objectives: The purpose of the study was to assess the relationship between selective serotonin reuptake inhibitors use and hepatocellular carcinoma in Taiwan. Methods: Using the database of the Taiwan National Health Insurance Program, we conducted a case-control study to identify 4901 subjects aged 20 years and more with newly diagnosed hepatocellular carcinoma in 2000-2013 as the cases. We r...

Understanding the intratumoral heterogeneity of hepatocellular carcinoma is instructive for developing personalized therapy and identifying molecular biomarkers. Here we applied whole-exome sequencing to 69 samples from 11 patients to resolve the genetic architecture of subclonal diversification. Spatial genomic diversity was found in all 11 hepatocellular carcinoma cases, with 29% of driver mu...