BACKGROUND Laminin receptors are involved in cell-extracellular matrix interactions in malignant cells that show invasion and metastasis. Hepatocellular carcinoma frequently shows early invasion into blood vessels, and intrahepatic and extrahepatic metastases. However, the role of laminin receptors in hepatocellular carcinoma is unknown. AIMS To examine the expression of mRNA for laminin rece...

Background and Aims: We hypothesized that a genetic risk score for fatty liver disease influences the of cirrhosis hepatocellular carcinoma.

AIMS To investigate the smooth muscle nature of the stromal cells in the capsule of hepatocellular carcinomas. METHODS Immunohistochemical analysis using monoclonal antibody to high molecular weight caldesmon (HCD), a highly specific marker for smooth muscle cells, was performed in 33 encapsulated hepatocellular carcinomas and adjacent hepatic tissues. RESULTS HCD positive stromal cells wer...

Hepatocellular carcinoma may develop from multistep carcinogenesis via dysplastic nodules in the cirrhotic liver. The first stage between high-grade dysplastic nodule to overt hepatocellular carcinoma is vaguely nodular, early hepatocellular carcinoma. The consensus on the nomenclature and pathologic characteristics of both entities were recently established by an international consensus group ...

Chemoresistance is one of the major obstacles in systemic chemotherapy and targeted therapy for patients with advanced hepatocellular carcinoma. To identify novel chemoresistance-associated targets in hepatocellular carcinoma, chemoresistant hepatocellular carcinoma cell lines were established. By comparing the global gene expression profiles between chemoresistant and chemosensitive cell lines...

An 18 year old man underwent liver transplantation due to an Abernethy malformation associated with multiple hepatocellular nodules including one which was a rapidly enlarging and was suspicious for malignant transformation. Analysis of the explanted liver showed a spectrum of multiple hepatocellular nodules ranging in appearance from focal nodular hyperplasia, hepatocellular adenoma and to a w...

Skeletal metastasis from primary hepatocellular carcinoma is rare ranging from 03 to 20% and is mostly seen in autopsy cases. Patients presenting with symptoms of bone metastasis are still rarer. Only a few cases of metastasis to bone from hepatocellular carcinoma have been reported as per literature review. Other cancers like breast, prostate, and lung carcinomas show an increased incidence of...

Telangiectatic hepatocellular adenoma is a rare, recently recognized subtype of benign liver tumor that may very rarely undergo transformation into hepatocellular carcinoma. We report an unusual case of a 75-year-old woman with no history of oral contraceptive use that underwent malignant transformation of a telangiectactic hepatocellular adenoma. No risk factors for adenoma development were id...

BACKGROUND More than 50% of the worldwide cases of hepatocellular carcinoma occur in China, and this malignancy currently represents the country's second leading cause of cancer death in cities and the leading cause in rural areas. Despite recent advances in the control and management of hepatocellular carcinoma within China, this disease remains a major health care issue. The global HCC BRIDGE...

PURPOSE This study aims to determine the relationship between CpG island DNA hypermethylation and global genomic DNA hypomethylation and their prognostic implications in hepatocellular carcinoma. The association of DNA methylation changes with clinicopathologic factors and the chronological ordering of DNA methylation changes along multistep hepatocarcinogenesis were also assessed. EXPERIMENT...