PURPOSE OF REVIEW As a rare pediatric tumor, hepatoblastoma presents challenges to the individual practitioner as no center will see more than a handful of cases each year. RECENT FINDINGS The Children's Hepatic tumor International Collaborative (CHIC) effort has fostered international cooperation in this rare children's tumor, leading to the establishment of a large international collaborati...

Patients with Beckwith-Wiedemann syndrome (BWS) are known to be at an increased risk for childhood malignancies, particularly Wilms tumor and hepatoblastoma. We report a case of genetically confirmed BWS in a 5-month-old girl who presented with a 9.5-cm abdominal mass associated with elevated α-fetoprotein levels. The clinical impression was strongly suggestive of hepatoblastoma. Histologic exa...

AbstractPurpose Hepatoblastoma is the most common liver malignancy in children. In order to advance therapy against hepatoblastoma, novel immunologic targets and biomarkers are needed. Our purpose this investigation examine hepatoblastoma transcriptomes for expression of a class genomic elements known as Human Endogenous Retrovirus (HERVs). HERVs abundant human genome biologic...

Hepatoblastoma is thought to originate from embryonal hepatic tissue, and most of these tumors occur in children under the age of 2 years. Hepatoblastoma in adults is extremely rare, and the prognosis is much worse than the mixed hepatoblastoma of childhood. We experienced a case of mixed hepatoblastoma in a 51 year old female patient. She had been suffering from a mild pain and a palpable lump...

conclusions the clinical features are effective indicators for distinguishing ihh from hbl, and the spectral doppler may be a useful adjunct parameter for differential diagnosis. objectives to study the clinical manifestations and the ultrasound features of the pediatric patients for distinguishing ihh from hbl. patients and methods between 2002 and 2012, thirteen children with ihh and 38 child...

The existence of a Kodaira fibration, i.e., of a fibration of a compact complex surface S onto a complex curve B which is a differentiable but not a holomorphic bundle, forces the geographical slope ν(S) = c 1 (S)/c2(S) to lie in the interval (2, 3). But up to now all the known examples had slope ν(S) ≤ 2 + 1/3. In this paper we consider a special class of surfaces admitting two such Kodaira fi...

AIMS To review all the case reports or case series of patients with adult hepatoblastoma. METHODS A search of all case reports on adult hepatoblastoma in the English literature was performed using the PubMed database. Demographic information, clinical findings, treatment modalities and outcomes were extracted and analyzed. RESULTS A total of 36 English articles and 40 patients with adult he...

Hepatoblastoma is the most common type of malignant liver tumor in children and occurs most frequently in patients two years of age and younger. The outcomes for children with hepatoblastoma have been improving in recent years due to the introduction of cisplatin-based chemotherapy regimens. Recently, performing liver transplantation after neoadjuvant chemotherapy has become increasingly advoca...

Hepatoblastomas among children with very low birth weights have significantly increased recently, according to the data from the Japan Children's Cancer Registry for the years 1985-1993. We then analyzed more Registry data for 1969-1994 to clarify the possible relationship between low birth weight and hepatoblastoma. The percentage of low birth weights was compared between 543 hepatoblastoma ch...