To evaluate the age-related response of essential cell functions against peroxidative damage in hyperthermia, we studied the biochemical response to heat stress in both young and aged rats. Passive hyperthermia was immediately observed in rats after exposure to hot environments. In aged rats, the rectal temperature maintained thermal homeostasis and increased to the same degree as in young rats...

The objective of this experiment was to determine the effect of long-term low-dose administration of lead (Pb) on thyroid function in sheep. In this experiment 10 healthy Iranian male sheep, aged about oneyear- old were randomly allocated into two equal groups of control (n = 5) and experiment (n = 5). Both groups were kept under the same conditions of food and environment. The treatment group ...

Hepatic enzyme induction is generally an adaptive response associated with increases in liver weight, induction of gene expression, and morphological changes in hepatocytes. The additive growth and functional demands that initiated the response to hepatic enzyme induction cover a wide range of stimuli including pregnancy and lactation, hormonal fluctuations, dietary constituents, infections ass...

The protective effect of a fermented substance from Saccharomyces cerevisiae (FSSC) on liver injury caused by acetaminophen (AAP) was studied in mice. Mice were pretreated with FSSC (0.5-2.0 g/kg, p.o.) for 4 d, and on the fourth day, the mice received an overdose of AAP (500 mg/kg, i.p.). Subsequently, they were sacrificed at 7 h, and blood was drawn from the abdominal vein and liver samples w...

Hepatic encephalopathy is a brain and nervous system disease that occurs as a consequence of liver disorders, these include hepatitis and liver cirrhosis. The aim of this study is to evaluate important serum physiological enzymes activity such as AKP, CPK, LDH, S-GPT and S-GOT in these patients. All patients who were above 12 years, had signs and symptoms of HE either at presentation or during ...

The effects of tannic acid (TA) supplementation (0·02 %, wt/wt) were compared with the effects of clofibrate (CF) supplementation (0·02 %, wt/wt) in apo E-deficient (apo E) mice fed a AIN-76 semi-synthetic diet (normal diet) over 20 weeks. The mice were monitored for the modulation of hepatic mRNA expression and the activities of lipid-regulating enzymes. Both TA and CF supplementation lowered ...

objective(s): to appraise the antihepatotoxic efficacy of ethanolic extract of operculum turpethum root on the liver of swiss albino mice.   materials and methods:   hepatic fibrosis was induced in adult male albino mice through intraperitoneal administrations of n-nitrosodimethylamine (ndma) at the concentration of 10 mg/kg body weight. the liver toxicity and therapeutic effect of the plant et...

crocin, a bioactive molecule of saffron can be purely isolated from the saffron extract. it has different pharmacological effects such as antioxidant and anticancer activities. morphine is an opioid analgesic drug. it is mainly metabolized in liver and causes devastating effects. it can increase the generation of free radicals. this study was designed to evaluate the protective role of crocin a...

the objective of this experiment was to determine the effect of long-term low-dose administration of lead (pb) on thyroid function in sheep. in this experiment 10 healthy iranian male sheep, aged about oneyear- old were randomly allocated into two equal groups of control (n = 5) and experiment (n = 5). both groups were kept under the same conditions of food and environment. the treatment group ...