Introduction: Non-alcoholic fatty liver disease (NAFLD) is an important health problem globally that characterized as a disease spectrum which includes simple steatosis, non-alcoholic steatohepatitis and liver fibrosis and cirrhosis. The prevalence of NAFLD has significantly increased recently. The aim of this study was to investigate the relationship between anthropometric par...

Portal hypertension in patients with cirrhosis is the cause of many dangerous complications, such as hepatic encephalopathy, ascites, and gastro-oesophageal variceal bleeding. Gastrooesophageal variceal bleeding is the cause of more than one-third of deaths in patients with liver cirrhosis [3]. H.pylori infection has a role in some diseases as peptic ulcer [4] portal hypertensive gastropathy [5...

Background: Hepatic adenosine triphosphate (ATP) levels are an accurate reflection of functioning hepatic mass following surgical resections and acute liver injury. Objective: To determine whether hepatic ATP levels can serve as a non-invasive means of documenting progression of chronic liver disease to cirrhosis. Methods: In vivo phosphorus-31 magnetic resonance spectroscopy (P MRS) was perfor...

Cirrhosis is a significant contributor to non-communicable disease related deaths in Sri Lanka and the only cure for cirrhosis constitutes liver transplant. Nonalcoholic fatty (NAFLD) which hepatic component of metabolic syndrome main aetiology patients presenting transplant at CNCLD. Enhanced recovery after surgery (ERAS) concept originally adopted colorectal surgery, multimodal- multidiscipli...

BACKGROUND Hepatic adenosine triphosphate (ATP) levels are an accurate reflection of functioning hepatic mass following surgical resections and acute liver injury. OBJECTIVE To determine whether hepatic ATP levels can serve as a non-invasive means of documenting progression of chronic liver disease to cirrhosis. METHODS In vivo phosphorus-31 magnetic resonance spectroscopy ((31)P MRS) was p...

Liver cirrhosis, the end-stage of every chronic liver disease, is not only the major risk factor for the development of hepatocellular carcinoma but also a limiting factor for anticancer therapy of liver and non-hepatic malignancies. Liver cirrhosis may limit surgical and interventional approaches to cancer treatment, influence pharmacokinetics of anticancer drugs, increase side effects of chem...

A considerable proportion of patients with cirrhosis exhibit insomnia, delayed sleep habits, and excessive daytime sleepiness. These have been variously attributed to hepatic encephalopathy and impaired hepatic melatonin metabolism, but the understanding of their pathophysiology remains limited and their treatment problematic. Sleep is regulated by the interaction of a homeostatic and a circadi...

Patients with cirrhosis of liver are more prone to have accompanying diabetes mellitus. The present study was conducted to investigate various biochemical parameters in patients with hepatic cirrhosis without diabetes. In these patients blood pyruvate, total bilirubin and globulin levels were elevated as compared to normal individuals. In contrast serum albumin level declined significantly wher...