conclusions this results the same as many similar studies demonstrated that common hcv genotypes in iranian patients were 1a, 3a and 1b, respectively. patients with 1a and 1b genotypes have lower responses to interferon treatment, and it is reasonable to perform early screening to diagnose and determine hcv genotype for effective treatment and diagnose high-risk cases. results in overall, 509 p...

conclusions our study suggested that the prevalence rate of hepatitis c virus is below 1% in the general population of mashhad. results in this study the overall seroprevalence of hepatitis c was founded to be 0.2% by using elisa method. however, the overall hepatitis c virus infection prevalence was found to be 0.13% with rt-pcr method. patients and methods three thousand, eight hundred and se...

conclusions this epidemiological study indicated different rates and transmission risks for these viruses. hcv was the most contagious viral infection and htlv-i was the weakest in the prisoners. apart from kshv infection which its prevalence was as twice as in the general population, the prevalence of hbv and htlv-i in prisoners was nearly in ranges of the general population. background prison...

Leukotrienes (LTs) are known to be produced by macrophages when challenged with Leishmania, but it is not known whether these lipid mediators play a role in host defense against this important protozoan parasite. In this study, we investigated the involvement of LTs in the in vitro and in vivo response to Leishmania amazonensis infection in susceptible (BALB/c) and resistant (C3H/HePAS) mice. P...

results phylogenetic analysis of the gene revealed that pakistani 1a hcv strains are in the start of third cluster and there is a difference between inter pakistani isolates at primary, secondary and tertiary levels. material and methods patient sera infected with hepatitis c virus, genotype 1a, were obtained from molecular diagnostics lab, cemb, university of the punjab lahore by using bd vacu...

conclusions according to the liver microrna data of chinese tree shrew, characteristics of the mir-122 and let-7 families further highlight the suitability of tree shrew as the animal model in hcv research. objectives this study aimed to construct a liver microrna (mirna) data of the tree shrew. materials and methods three second filial generation tree shrews were used in this study. total rna ...

conclusions findings of the present study showed that hcv genotype 3 was the predominant genotype followed by the subtypes 1a and 1b in yazd, central province of iran. in addition, there was no difference between hcv load and genotypes 1 and 3. hcv genotyping is recommended in other provinces of iran. objectives the main aim of this study was to estimate the prevalence of hcv genotypes in yazd,...

conclusions core-lds interaction may be an underlying molecular mechanism to induce liver steatosis in patients with hcv infection. this interaction is also crucial for efficient viral replication and persistence in infected cells. steatosis can also interfere with efficient standard interferon therapy treatment. management of steatosis should be considered along with standard care for achievin...

conclusions by employment of gene optimization strategies, use of viral-based vectors and suppression of plant-derived gene silencing effect, efficient transient expression of hcvcp in tobacco with proper antigenic properties could be possible. background hepatitis c virus (hcv) is major cause of liver cirrhosis in humans. hcv capsid (core) protein (hcvcp) is a highly demanded antigen for vario...