Intestinal epithelial barrier function is impaired in irritable bowel syndrome patients. Claudins are highly expressed in cells with tight junctions and are involved in the intestinal epithelial barrier function. The expression pattern of tight junction proteins in diarrhea-predominant irritable bowel syndrome have not been fully elucidated. We therefore recruited 17 diarrhea-predominant irrita...

BACKGROUND Although little mortality is associated with irritable bowel syndrome, curative therapy does not exist and thus the economic impact of this disorder may be considerable. METHODS A systematic review of the literature was performed. Studies were included if their focus was irritable bowel syndrome, and direct and/or productivity (indirect) costs were reported. Two investigators abstr...

We report a case of toxic epidermal necrolysis with ocular involvement following vaccination for hemorrhagic fever with renal syndrome. A healthy 20-year-old male soldier presented with confluent purpuric and erythematous dusky red macules evolving to flaccid blister and epidermal detachment on the whole body with conjunctival injection. The patient had no antecedent medical or surgical conditi...

BACKGROUND Abnormalities of gut motility and visceral pain perception are both thought to be involved in the pathogenesis of irritable bowel syndrome and may be susceptible to modulation by drugs affecting the various 5-HT receptor subtypes. The aim of this study was to investigate the therapeutic potential of a 5-HT3 antagonist in irritable bowel syndrome. METHODS Fifty patients with irritab...

background: irritable bowel syndrome (ibs) is a chronic functional bowel disorder that up to 20% of the population is suffering from it. also benign prostatic hyperplasia (bph) is a common problem that approximately 90 percent of men may be affected by this condition until the eighth decade of their life. prostatectomy as a surgery and pelvic intervention can cause ibs. methods: it was a case-c...

BACKGROUND Both high-fibre dietary advice and the prescription of fibre as a bulking agent are very common in primary and secondary care management of irritable bowel syndrome. Irritable bowel syndrome patients with constipation may have delayed intestinal transit. Therefore, fibres that accelerate intestinal transit may be beneficial in these patients. The uncertain benefits reported in severa...

• To understand the nature and pathophysiology of the different types of intestinal failure and short bowel syndrome; • To appreciate the need for restriction of salt-poor fluids in patients with short bowel syndrome; • To have an understanding of the pharmacological and nutritional therapy of short bowel syndrome; • To be able to apply this understanding in clinical practice; • To know the pro...

introduction: cerebral vein thrombosis is a rare complication of nephrotic syndrome (ns).we report a known case of ns with hemorrhagic thrombosis. case report: a boy with previous history of ns was admitted with headache and decrease of level of consciousness and his brain images were revealed hemorrhagic thrombosis conclusions: cerebral vein thrombosis must be considered in patients with histo...

introduction: irritable bowel syndrome (ibs) is a common gastrointestinal disorder in children that may lead to anxiety, frequent physician visits and school absenteeism. the aim of this study is to reviewe effects of probiotic for irritable bowel syndrome.   materials and methods: this study review articles about probiotic for irritable bowel syndrome in pubmed and google scholar.   results: m...