Circulating erythropoietic precursors in normal men and patients with hemoglobinopathies were characterized in culture. Blood mononuclear cells harvested with a modification of the Ficoll-Isopaque technique were cultured in methylcellulose for 14 days. The majority of erythropoietic colonies consisted of several subcolonies assuming the morphology of erythropoietic "bursts" described in murine ...

Hemoglobinopathies are highly prevalent diseases and impose a public health burden. Early diagnosis and treatment can ameliorate the course of these diseases and improve survival. Despite purported high incidence of hemoglobinopathies in Lebanon, there are no nationwide screening programs. In this study, newborn screening utilizing high pressure liquid chromatography was executed in all public ...

This hospital based cross-sectional study describes the number of hemoglobinopathies in population southern Odisha during period and distribution each group hemoglobinopathy found according to their age, sex, clinical signs & symptoms, history consanguinity marriage parents, previous blood transfusion, siblings, socioeconomic status family, groups hematological parameters.

T HE MODERN ERA ofprenatal testing for hematologic diseases began in 1974. Prior to that time, the only test available consisted of determination of fetal sex following amniocentesis in cases at risk for sex-linked disorders, such as the hemophilias. Methods for obtaining fetal blood in utero in ongoing pregnancies were initiated in 1974, and these developments led to the possibility of prenata...

T HE MODERN ERA ofprenatal testing for hematologic diseases began in 1974. Prior to that time, the only test available consisted of determination of fetal sex following amniocentesis in cases at risk for sex-linked disorders, such as the hemophilias. Methods for obtaining fetal blood in utero in ongoing pregnancies were initiated in 1974, and these developments led to the possibility of prenata...

T HE MODERN ERA ofprenatal testing for hematologic diseases began in 1974. Prior to that time, the only test available consisted of determination of fetal sex following amniocentesis in cases at risk for sex-linked disorders, such as the hemophilias. Methods for obtaining fetal blood in utero in ongoing pregnancies were initiated in 1974, and these developments led to the possibility of prenata...

Sickle cell disease and thalassemia have distinctly different mutations, but both share common complications from a chronic vasculopathy. In the past, fetal hemoglobin-modulating drugs have been the main focus of new therapy, but the increased understanding of the complex pathophysiology of these diseases has led to the development of novel agents targeting multiple pathways that cause vascular...

OBJECTIVE To evaluate fetal aortic Doppler for the prenatal diagnosis of hemoglobinopathies in the first trimester of pregnancy. MATERIALS AND METHODS Between January and November 2014, a total of 108 patients were enrolled in the study. The couples were carriers of either alpha/beta thalassemia, sickle cell disease or combined carriers of these and were admitted to Çukurova University Facult...