Objective: To find out the frequency of involvement of bone marrow by non – haematological disorders in our institution and to evaluate the role of bone marrow aspiration and biopsy in diagnosing these disorders. Materials & Methods: It was a retrospective study that extended from January 2013 to December 2016. A total of 339 bone marrow aspirates and trephine biopsies were performed during thi...

BACKGROUND: The aboriginal tribes of India constitute an important segment of the society in the world. Though a large number of genetic studies have been carried out in India, the genetic data of the populations in the state of Orissa are very limited, especially per taining to the indigenous tribal people. Most of the earlier studies were restricted to either a single tribe or a few genetic m...

BACKGROUND Arsenic toxicity is a major global health problem and exposure via contaminated drinking water has been associated with hematological and other systemic disorders. The present investigation has been conducted in adult male rats to evaluate the protective ability of α-lipoic acid (ALA) against such hematological disorders. METHODS Twenty-four adult male Wister rats (b.wt.130±10g) we...

Constitutive activation of the Janus kinase (JAK)/signal transducer and activator of transcription (STAT) axis is fundamental to the molecular pathogenesis of a host of hematological disorders, including acute leukemias and myeloproliferative neoplasms (MPN). We demonstrate here that the major JAK2 mutation observed in these diseases (JAK2V617F) enforces Mcl-1 transcription via STAT3 signaling....

Rituximab is an anti-CD20 monoclonal antibody that has been used to treat several complications of systemic lupus erythematosus (SLE) including nephritis, cerebritis, and hematological disorders. Neutropenia is among the adverse events associated with rituximab; this usually occurs several weeks after therapy. However, early-onset neutropenia has been reported only in a few cases. Herein, we de...

Hematological disorders due to covid 19 infection are increasingly known hyperleukocytosis, lymphopenia and thrombocytopenia. However, the association between non-existent, non-apparent or asymptomatic acute leukemia remains rare. No causal relationship has been established leukemia. We report a case of young patient admitted for treatment severe viral pneumonitis in whom an was diagnosed.

Correspondence: Dr. Prabesh Kr. Choudhary, MD Department of Pathology, Nobel Medical College, Biratnagar, Nepal Email: [email protected] Background: Dysplastic changes in megakaryocyte are well-recognized features of myelodysplastic syndrome. However, several studies have shown it’s occurrence in various other disorders. This study was done to understand the various megakaryocytic alterations ...

Hematopoietic stem cell transplantation (HSCT) is the only curative treatment for many hematological disorders, primary immunodeficiencies, and metabolic disorders. Thyroid dysfunction is one of the frequently seen complications of HSCT. However, hyperthyroidism due to Graves' disease, autoimmune thyroiditis, and thyrotoxicosis are rare. Herein, we report a series of 4 patients who were euthyro...

We report here a patient with myelodysplastic syndromes (MDS), which was complicated with several autoimmune disorders and asymptomatic immunologic abnormalities. An 82-year-old woman with refractory anemia (RA) rapidly developed thrombocytopenia with the appearance of symptoms such as purpura, fatigue, anorexia, and weight loss. Furthermore, clinical examinations revealed that she also had Add...