the  non-classical mhc  class-i mainly involves in the  regulation of  innate  immune responses where hla-e  plays a significant role in the cell identification by natural killer cells. hla-e is a main regulatory ligand for natural killer cells and given the importance of these effector cells in hematopoietic stem cell transplantation, we investigated the effect of hla-e polymorphisms on post-h...

Today, stem cell transplantation is a hot topic in scientific circles as a novel therapeutic approach to repair the structure and function of central nervous system. The safe and neuroprotective effects of cell therapy in models and traumatic brain injury patients were evaluated in many experimental and clinical studies in recent decade and somewhat promising results were provided to the scient...

The utility of allogeneic stem cell transplantation for treating hematologic malignancies is enhanced by the graft vs. tumor (GvT) effect, but limited by graft vs. host disease (GvHD). Studies involving the inhibition of CD73 by genetic or pharmacologic means suggest that the levels of CD73-generated adenosine may be manipulated to control GvHD, while maintaining the GvT effect.

The complexity of multiple sclerosis (MS) and the incompetence of a large number of promise treatments in MS urge us to plan new and more effective therapeutic approaches that aim to suppress ongoing autoimmune responses and induction of local endogenous regeneration. Emerging data propose that hematopoietic, mesenchymal and neural stem cells have the potential to restore self-tolerance, to pro...

Leukemia in donor cells (donor cell leukemia; DCL) has been reported as a rare but severe complication of allogeneic stem cell transplantation (SCT). However, the incidence, potential pathogenetic factors, therapeutic options and outcome of patients suffering from DCL and the leukemia risk of their donors are not well defined. A questionnaire survey was carried out within European Blood and Mar...

Precise replacement of diseased or dysfunctional organs is the goal regenerative medicine and has appeared to be a distant for long time. In field hematopoietic stem cell transplantation, this now becoming tangible as gene-editing technologies novel conditioning agents are entering clinical arena. Targeted immunologic depletion cells (HSCs), which at very root system, will enable more selective...

Background: Bone marrow and stem cell transplantation have become conventional therapy, with the potential to cure a variety of hematologic malignancies immunologic diseases. Severe infection is still potentially fatal complication following transplantation, contributes significantly morbidity, may demand ICU admission. Objectives: The study aims summarize current evidence on prevalence, risk f...

Background Ovarian tissue cryopreservation is an option for patients who require immediate gonagonadotoxic treatment of cancers. when there is insufficient time to conduct ovulation induction This procedure can be used in patients with genetic mutations with a high risk for premature ovarian failure.This strategy is the only option for fertility preservation in prepubertal girls or in women who...

today, stem cell transplantation is a hot topic in scientific circles as a novel therapeutic approach to repair the structure and function of central nervous system. the safe and neuroprotective effects of cell therapy in models and traumatic brain injury patients were evaluated in many experimental and clinical studies in recent decade and somewhat promising results were provided to the scient...

background: thalassemic patients undergoing hematopoietic stem cell transplantation (hsct) are faced with cumulative high level of oxidative stress and depletion of critical antioxidants. administration of antioxidants, is promising towards minimizing oxidative damage in both thalassemic and hsct patients. method: this was a prospective cross-sectional observational study. patients as a part of...