BACKGROUND Heatstroke often leads to multiple organ dysfunction syndrome (MODS) with a death rate of 40% or a neurological morbidity of 30%. These high rates in patients with heatstroke are largely due to the progression of heat stress to MODS, resulting in no specific treatment available. This study aimed to develop a mouse model of heat stress and determine the pathological changes in the lun...

PICO question Do dogs that are brachycephalic have an increased risk for developing heat-related illness compared to not brachycephalics? Clinical bottom line Category of research Risk. Number and type study designs reviewed Four studies were critically appraised. Three these cohort studies, one was a case-control study. Strength evidence Moderate. Outcomes reported Brachycephalic at breeds ove...

W ith more than 1200 deaths reported due to heatstroke in 10 days, the populous metropolis of Karachi, Pakistan, survived one of the worst ever unprecedented deadly heat waves in history in June 2015. Severe temperatures of up to 45 °C, zero wind activity and high humidity all exacerbated by 10–18-hr power outages caused havoc and panic in the city. To make matters worse, this catastrophic weat...

Exertional heatstroke (EHS) is a life-threatening disease characterized clinically by central nervous system dysfunction and severe hyperthermia. It frequently occurs among athletes, soldiers, and laborers. While cardiopulmonary symptoms are common in patients undergoing EHS, irreversible acute liver failure is a rarely described phenomenon. When managing cases of EHS complicated by acute liver...

An unusual case of an exertional heatstroke in a healthy 25-year-old man is presented. Initially, the patient was deeply comatose and developed severe rhabdomyolysis and massive hepatic necrosis. Subsequently, he received a liver transplant with remarkable improvement in his mental status, although the rhabdomyolysis continued. The patient died 41 days after the transplant due to a complicating...