OBJECTIVES Right ventricular heart rupture is a devastating complication associated with negative pressure wound therapy (NPWT) in cardiac surgery. The use of a rigid barrier has been suggested to offer protection against this lethal complication, by preventing the heart from being drawn up and damaged by the sharp edges of the sternum. The aim of the present study was to investigate whether a ...

Mitochondria play a central role in the integration and execution of a wide variety of apoptotic signals. In the present study, we examined the deleterious effects of burn injury on heart tissue. We explored the effects of vagal nerve stimulation (VNS) on cardiac injury in a murine burn injury model, with a focus on the protective effect of VNS on mitochondrial dysfunction in heart tissue. Mice...

Objective(s): This study aimed to evaluate the protective effects of total flavonoid extract from Coreopsis tinctoria Nutt.(CTF)against myocardial ischemia/reperfusion injury (MIRI) using an isolated Langendorff rat heart model. Materials and Methods: Left ventricular developed pressure (LVDP) and the maximum rate of rise and fall of LV pressure (±dp/dtmax) were recorded. Cardiac injury was as...

Objective(s): This study explored the inter-relationship among nitric oxide, opioids, and KATP channels in the signaling pathway underlying remote ischemic preconditioning (RIPC) conferred cardioprotection. Materials and Methods: Blood pressure cuff was placed around the hind limb of the animal and RIPC was performed by 4 cycles of infla...

The present study aimed to examine the effectiveness of silymarin compared to hydrocortisone on clinical and hematological alterations and organ injury (liver and heart) in a low-dose canine lipopolysaccharide (LPS)-induced sepsis model. Fifteen clinically healthy dogs were randomly categorized into three equal groups: Two dogs in group A, LPS (0.10 μg kg-1, IV) was injected (control...

Objectives: Wheelchairs are the prime mobility aid of persons with spinal cord injuries. Manual wheelchair propulsion puts a lot of demand on the cardiopulmonary as well as the skeletal system. The main purpose of the study was to compare the effects of both arm ergometry training and progressive resistance exercise training of upper limbs on resting heart rate and distance covered during wheel...

Researchers have the potential to be exposed a wide variety of hazards inherent equipment they use and maintain. When does not function as expected, researchers sometimes reach out their vendors for assistance. Early diagnostic or troubleshooting interactions between researcher vendor are often conducted over telephone can lead performing work outside area expertise exposure unknown hazards. Th...

Coronavirus disease 2019 (COVID-19) caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has been associated with excess mortality worldwide. The cardiovascular system is second most common target of SARS-CoV-2, which leads to complications, including myocardial injury, myocarditis, arrhythmias, and venous thromboembolism, as well other major thrombotic events because dire...

Acute myocardial infarction has a rapid onset, is severe and high mortality rate that seriously threatens the lives of population. Coronary intervention combined with drug treatment can open criminal blood vessel save patient's life, but surviving patient not "cured" must go through process ischemia reperfusion injury. Myocardial cells are end-stage death due to injury irreversibly damages stru...