In our previous study, cardiac glycosides including bufalin, a group of sodium pump (Na+/K+-ATPase) inhibitors widely used to treat heart failure for many years, have been demonstrated to induce a delay of mitotic entry and mitotic arrest in many cancer cells. However, the underlying mechanism remains poorly understood. Here, we reported for the first time that cardiac glycoside bufalin induced...

Cases of Coronavirus disease are rapidly increasing across the world. Hypertension is commonest co-morbidity among COVID-19 infected patients and hypertension one determinants severity COVID-19.COVID -19 virus uses ACE-2 as an entry receptor plays a vital role in blood pressure control individual. Certain antihypertensive medications may affect level hence pathogenesis. At present, while worlds...

ing feature of civilization. The continual improvements and refinements of writing systems throughout history are a testament to their importance. In the last 10,000 years, the media of writing systems have changed from cave walls, rune stones, and sand to papyrus, wax tablets, parchment, paper, and—in our age—networked computers. Carvings, pieces of scribble, and elaborate texts have been gene...

In this paper we describe the findings of an exploratory study of the effect of obstructive sleep apnea (OSA) on the electrocardiogram (ECG) signal. Episodes of sleep apnea are characterized by periodic cycles of breathing cessation and restoration. Our analysis was guided by the hypothesis that these cycles synchronously alter the ECG. We discovered several characteristic indicators of apnea i...

soon after catheterization in the other two. After 3 or more days of heparin therapy, serious bleeding developed at the site of percutaneous catheter entry. The timing and incidence of this complication are in marked contrast to experience with this procedure in individuals who did not receive heparin. Preliminary experience is presented from right and left heart catheterizations in patients wh...

To present results of the SOLVD 4-year clinical trials of enalapril on two groups of patients with left ventricular ejection fraction under 36%, one group with and the other group without symptomatic congestive heart failure. Observed mortality is compared with expeded mortality derived from the 1975-1980 Basic Select Tables, because of the high degree of exclusion utilized for patients with as...

Inferior venous access to the right heart is not possible in some patients due to vena caval obstruction. Here we describe a case of a patient with atrioventricular nodal re-entry tachycardia where radiofrequency ablation from the inferior vena cava was impossible because of the presence of important stenosis of the distal part of the vein. Catheter ablation of the slow pathway could be perform...

Unsupervised learning is often used to uncover clusters in data. However, different kinds of noise may impede the discovery useful patterns from real-world time-series In this work, we focus on mitigating interference interval censoring task clustering for disease phenotyping. We develop a deep generative, continuous-time model data that while correcting censorship time. provide conditions unde...

With the proposal for a Regulation of European Parliament and Council establishing Carbon Border Adjustment Mechanism (CBAM) adopted on July 14, 2021 by Commission, it begins to reach heart global debate opportunity adopt mechanisms combat phenomenon ‘carbon leakage’, that is attempt evade existing carbon pricing systems through delocalization most polluting activities. In this way, Union demon...

BACKGROUND AND PURPOSE We sought to detect prognostic factors related to functional outcome during the first 6 hours after a first-ever stroke in the carotid artery territory. METHODS All patients with these characteristics seen during a 3-year period were included. Outcome was evaluated according to a modified Rankin scale. The following variables were examined at univariate analysis: sex, a...