Impulse generation in supraventricular tissue is inhibited by adenosine and acetylcholine via the activation of A1 and M2 receptors coupled to inwardly rectifying GIRK/KIR3.1/3.4 channels, respectively. Unlike M2 receptors, bradycardia produced by A1 receptors activation predominates over negative inotropy. Such difference suggests that other ion currents may contribute to adenosine chronoselec...

patients with valvular heart disease and suffering atrial fibrillation of more than 12 months duration have a low probability of remaining in sinus rhythm after valve surgery alone. we performed intra-operative radiofrequency ablation or cryoablation as an alternative to surgical maze ііі procedure to create linear lesion lines for conversion of this arrhythmia to sinus rhythm. a total of 30 pa...

Methods We prospectively enrolled healthy 115 children and adolescents, mean age 12.4±4.1 years, range 4.4-20.3, with no acquired or congenital heart disease, no chronic illness or any competitive sports activities. Transversal routine 2D steady-state free-precession acquisition was used to cover the whole heart. We determined maximal and minimal volumes of both atria and calculated cyclic volu...

In this thesis, we study heart rhythms at different levels, from single cells to the entire human atria. The main project of this thesis is the development of a realistic and efficient model of wave propagation in the human atria. We start by studying paced single cells and their loss of 1:1 rhythmicity for increasing frequency. We go on to study wave propagation in tissue with special electrop...

Abstract Funding Acknowledgements Type of funding sources: None. Introduction Non-ischemic dilated cardiomyopathy (NIDCM) is a severe form primary myocardial disease related with progressive heart failure (HF) and poor prognosis. In patients NIDCM, fibrosis (MF) associated to adverse cardiovascular outcomes should be evaluated quickly in each case NIDCM [1,2]. Purpose To evaluate the relationsh...

Abstract Modeling the 'digital twin' of a patient's heart has gained traction in last years and helps to understand pathogenic mechanisms cardiovascular disease pave way for personalized therapies. Although 3D patient-specific model (PSM) can be obtained from computed tomography (CT) or magnetic resonance imaging (MRI), fiber orientation cardiac muscle, which significantly affects electrophysio...

Hyperthyroidism has been associated with atrial fibrillation (AF); however, hyperthyroidism-induced ion channel changes that may predispose to AF have not been fully elucidated. To understand the electrophysiological changes that occur in left and right atria with hyperthyroidism, the patch-clamp technique was used to compare action potential duration (APD) and whole cell currents in myocytes f...