Introduction Various compounds are being sought to increase fracture healing and enhance the healing rate. The closed femoral fracture in rats is a model commonly used to assess the efficacy of a compound for healing. This model is considered as a presumably stabilized fracture healing process. In a normal fracture healing process, there are 4 stages, i.e., inflammatory reaction and hematoma im...

Impaired fracture healing in aged females is still a challenge in clinics. MicroRNAs (miRNAs) play important roles in fracture healing. This study aims to identify the miRNAs that potentially contribute to the impaired fracture healing in aged females. Transverse femoral shaft fractures were created in adult and aged female mice. At post-fracture 0-, 2- and 4-week, the fracture sites were scann...

An important, unfilled clinical need is the development of new approaches to improve fracture healing and to treat osteoporosis by increasing bone mass. Recombinant forms of bone morphogenetic protein 2 (BMP2) and BMP7 are FDA approved to promote spinal fusion and fracture healing, respectively, and the first FDA-approved anabolic drug for osteoporosis, parathyroid hormone, increases bone mass ...

background: several systemic factors and hormones are thought to regulate the fracture healing process. vitamin d has emerged as a compound or hormone that actively participates in the regulation of calcium homeostasis and bone metabolism. objectives: the aim of this study is to determine the serum changes in the level of vitamin d during the acute healing period of tibial and femoral shaft fra...

Osteoporosis is an inflammatory bone disease affecting millions of population worldwide, which often cause increased fracture risks and prolonged fracture healing. Growing evidence suggests that IKK-NF-κB signaling exert inhibitory influence on MSCs osteogenic differentiation and bone formation. Moreover, enhance the fracture healing process in osteoporosis patient. In the current work, IKK-NF-...

Fracture healing is a complex physiological process caused by the interaction of cellular elements that are activated and controlled by an array of cytokines and signalling proteins [11]. This process is both temporal and spatial in nature and usually results in the formation of new bone, which is structurally and mechanically similar to the pre-fracture state [10]. For al lot of reasons this p...

Angiogenesis and bone formation are coupled during skeletal development and fracture healing. This relationship, although known for some time, has not been properly explored. Advances in the discovery of how angiogenesis is regulated in physiological processes like embryogenesis, endometrial regeneration and wound healing or in pathologies such as cancer have provided a deeper understanding of ...

INTRODUCTION Delayedand nonunion are common complications that occur after 510% of fractures. Iliac crest bone grafting, the current gold standard of treatment for nonunion, provides a limited source of grafting material and is associated with persistent donor site pain. Hernigou et al. reported the use of percutaneous injection of concentrated autologous bone marrow to treat nonunions with fra...