BACKGROUND/AIMS Cytomegalovirus (CMV) surveillance and preemptive therapy is a widely-used strategy for preventing CMV disease in transplant recipients. However, there are limited data on the incidence and patterns of CMV disease during the preemptive period. Thus, we investigated the incidence and pattern of tissue-invasive CMV disease in CMV seropositive kidney transplantation (KT) and hemato...

Hematopoietic cell transplantation (HCT) is a critical treatment of patients with high-risk hematopoietic malignancies, hematological deficiencies, and other immune diseases. In allogeneic HCT (allo-HCT), donor-derived T cells recognize host tissues as foreign, causing graft-versus-host disease (GVHD) which is a main contributor to morbidity and mortality. The intestine is one of the organs mos...

PURPOSE Multidrug resistance is one of the main impediments to the successful treatment of colon cancer. Glucosylceramide synthase (GCS) which is related to multidrug resistance (MDR) can reduce the level of ceramide and can help cells escape from the ceramide-induced cell apoptosis. However, the underlying mechanism is still unclear. METHODS The cell proliferation and cell toxicity were meas...

BACKGROUND Alcohol use has a detrimental impact on the HIV epidemic, especially in sub-Saharan Africa. HIV counseling and testing (HCT) may provide a contact opportunity to intervene with hazardous alcohol use; however, little is known about how alcohol consumption changes following HCT. METHODS We utilized data from 2056 participants of a randomized controlled trial comparing two methods of ...

Introduction: TP53 alterations are associated with poor prognosis in mantle cell lymphoma (MCL). In trials of intensive chemotherapy and autologous hematopoietic transplant (auto-HCT), patients (pts) mutations had an overall survival (OS) 1.8 years (yrs) compared to 12.7 yrs for unmutated. Optimal treatment achieve durable remission is unknown. We report cellular therapy outcomes a large cohort...

(allo-HCT) can be curative for patients with acute leukemia [1]. The anti-leukemia activity relies on the graft-versus-leukemia (GVL) effects that are elicited after allo-HCT, suggesting that anti-tumor immunity may be responsible for eradicating leukemia and preventing subsequent relapse. However, allo-HCT is associated with significant morbidity and mortality resulting from toxicity of dose-i...

conclusions the association of the 1st trimester high hb and hct with preeclampsia was revealed in this study, therefore it could be used as a prediction factor for early preeclampsia diagnosis. results preeclampsia incidence was 5.1% in our study. mean hb was 12.38 ± 1.69 g/dl in the preeclampsia group and 11.8 ± 1.18 in the non-preeclampsia group, and mean hct was 37.74 ± 5.15% in the preecla...

Hematopoietic cell transplantation (HCT) is an important curative treatment for children with high-risk hematologic malignancies, solid tumors, and, increasingly, nonmalignant diseases. Given improvements in care, there are a growing number of long-term survivors of pediatric HCT. Compared with childhood cancer survivors who did not undergo transplantation, HCT survivors have a substantially in...

BACKGROUND Only a limited number of studies have investigated the correlation between haematocrit (HCT) and mortality in the general population, and few of those studies have had data on a wide range of low and high levels of HCT. We investigated the association between baseline HCT and mortality in a prospective cohort study of 49,983 adult subjects in Iran with a broad spectrum of HCT values....

Hematopoietic cell transplantation (HCT) prolongs survival in the twitcher mouse, an authentic animal model of human globoid cell leukodystrophy (Krabbe disease; galactosylceramidase deficiency), but the effects of HCT on levels of galactosylceramidase, psychosine, and cerebrosides in the tissues of twitcher mice have not been previously studied. Galactosylceramidase was less than 8% of control...