Examples: Shortest Path, Traveling Salesman, and many many more. . . Just in bioinformatics: Alignments, Threading, Clone-Probe Mapping, Probe Selection, De Novo Peptide Sequencing, SideChain Placement, Maximum-weight Connected Subgraph in PPI Networks, Genome Rearrangements, Cluster Editing, Finding Regulatory Modules, Finding Approximate Gene Clusters, Haplotyping, and many more. . . Example....