In the present study, the effects of different doses of nicotine on immobility time in mice were tested. Intraperitioneal administration of low doses of nicotine (0.025 mg/kg) decreased, but higher doses (0.8 and 1 mg/kg) increased immobility time. The anti-immobility response induced by low doses of nicotine was inhibited by high doses of the D2 receptor antagonist sulpiride, the central nicot...

Background: Cigarette smoking is associated with impairment of testicular function. Nicotine is a major component of cigarette smoke.In the present study we aimed to study the effect of administration of nicotine-melatonin on sperm parameters in adult mouse. Materials and Methods: Male NMRI mice were divided into 4 groups: 1) control(normal saline) group 2) nicotine treated group 3) melatonin t...

Background: Nicotine exposure causes impaired fertility , ovarian and uterus dysfunction. The pineal hormone melatonin is known as an antioxidant agent. The aim of this study was to investigate the possible protective role of exogen melatonin on altered ovary and endometrium with nicotine. Materials and Methods: Female adult NMRI mice were divided into four groups. The control group received ve...

Background & objectives: The number of waterpipe cafes has considerably grown in Tehran and other cities of Iran. This increase has occurred due to a wrong belief that the use of hookahs is harmless and relatively safe. So, the aim of current study is to investigate the nicotine concentration in the indoor air of the waterpipe and cigarette cafés as well as the biological concentration of nicot...

Nicotine addiction and dependence is a chronic relapsing disease driven by to nicotine. Proactive treatment for all tobacco users, regardless of their readiness quit, recommended. First-line cessation medications include nicotine replacement therapy, bupropion, varenicline. Comprehensive with behavioral interventions pharmacologic therapy increases success rates smoking cessation. Although ther...

Background: Nicotine is considered as one of the most agents in cigarette smoking and has side effects on many organs and body systems such as reproductive tract. Nicotine can induce sub fertility or infertility both in males and females. The aim of this study was to evaluate the proliferative activity of adult mouse male germ cells following treatment with different doses of nicotine. Material...

Background & Aims: Allergic diseases have increased in the last decade worldwide and researchers have been trying to introduce new strategies and drugs to treat these types of diseases. Nicotine shows anti-inflammatory properties and the studies have revealed that it can reduce the inflammation and the allergic responses. The mammalian target of rapamycin (mTOR) is a multifunctional protein kin...

Tobacco smoking and high-fat diet (HFD) independently impair short-term memory. E-cigarettes produce e-vapour containing flavourings nicotine. Here, we investigated whether inhalation interacts with HFD to affect memory neural integrity. Balb/c mice (7 weeks, male) were fed a (43% fat, 20 kJ/g) for 16 weeks. In the last 6 half of exposed tobacco-flavoured from nicotine-containing (18 mg/L) or n...

The purpose of this study was to explore the effects nicotine on activity Streptococcus mutans (S. mutans) in soft drinks. Regular drinks contain large proportions high-fructose corn syrup (HFCS), which increases S. resulting high-caries risk compared with sugar-free Nicotine use exhibits a strong correlation increased biofilm formation. chosen were (Coca-Cola Classic, Diet Coke, Coca-Cola Zero...