Current knowledge of the haematological and onco-haematological complications of type 1 Gaucher disease has been reviewed with the aim of identifying best clinical practice for treatment and disease management. It was concluded that: (i) Awareness of typical patterns of cytopenia can help clinicians distinguish haematological co-morbidities. (ii) Red blood cell studies and complete iron metabol...

Sodium valproate is an effective antiepileptic drug used as monotherapy or adjuvant/alternative with other antiepileptic drugs. Haematological toxicity of this drug, though rare, is now an established fact and comprises mainly of neutropenia, thrombocytopenia and aplastic anemia. Very few cases of Pure Red Cell Aplasia (PRCA) following valproate therapy were reported in last 35 years but none p...

Long-term exposure to low doses of ionizing radiation may affect cells and tissues and result in various adverse health effects. The purpose of this study was to investigate whether chromosome aberrations and haematological alterations could be used as biomarkers of possible radiation injury in workers exposed to ionizing radiation. Groups totalling 323 medical professionals handling X-ray equi...

Editor’s key points † Patients with haematological malignancy requiring intensive care unit (ICU) care are often assumed to have a poor prognosis. † Analysis of 199 patients in a specialist centre had a lower ICU mortality (33%) than earlier studies. † Failure of ≥2 organ systems and mechanical ventilation were independently associated with in-hospital mortality. † The prognosis for haematologi...

Background: Extramedullary hematopoiesis is known to occur mainly in the organs of reticuloendothelial system. It is very rare for EMH to occur in thyroid nodule without any haematological abnormality. Case: A 71 year healthy male presented with 3 month history of dysphagia to solids. Clinical examination revealed thyroid nodule measuring 1 cm in diameter in right lobe of thyroid gland. FNAC wa...

OBJECTIVE To determine the clinical and haematological factors associated with treatment and outcome of chronic myeloid leukaemia (CML) at Kenyatta National Hospital. DESIGN Retrospective survey of patients treated for chronic myeloid leukaemia. SETTING Kenyatta National hospital, Nairobi, Kenya, between April 1990 and August 2000. SUBJECTS Patients with chronic myeloid leukaemia. RESUL...

Medicinal plants are regarded as safe because of their natural origin, nevertheless, they can contain toxic substances that exert adverse effects. This study aims to evaluate acute and subacute toxicity Jatropha curcas seed oil using modified Lorke method 28 days repeated dosing grouped rats with normal saline -10, 300, 600 mg/kg body weight the oil. At end experimentation, haematological bioch...

BACKGROUND & OBJECTIVES Lymphadenopathy and haematological alterations are the earliest manifestations with other associated opportunistic infections and malignancies. Hence, there is a need for simple investigations like fine needle aspiration cytology (FNAC) for evaluation of HIV lymphadenopathy and a haemogram to interpret the haematological alterations. This study was undertaken to analyze ...

BACKGROUND Somatostatin analogue-based radionuclide therapy with (177)Lu-DOTATATE is an important treatment option for patients with advanced neuroendocrine tumours overexpressing somatostatin receptors. In addition to the kidneys, the bone marrow is a major dose-limiting organ. The correlation between developed haematological toxicity and absorbed dose to the bone marrow is poor, which indicat...

INTRODUCTION Early recognition and identification of the underlying cause of acute liver injury (ALI) is crucial in instituting medical treatment and assessing the need for liver transplantation. Haematological malignancies have been reported to present as ALI with progression to acute liver failure but experience is limited. AIM Review our experience of ALI secondary to haematological malign...