Protopanaxatriol saponins obtained with AB-8 macroporous resin mainly consisted of ginsenosides Rg(1) and Re. A novel mono-ester of ginsenoside-Rh(1) (ginsenoside-ORh(1)) was synthesized through further enzymatic hydrolysis and octanoyl chloride modifications. A 53% yield was obtained by a facile synthetic method. The structures were identified on the basis of 1D-NMR and 2D-NMR, as well as ESI-...

Tumor cells expressing TLRs is generally recognized to mediate tumor inflammation. However, whether and how tumor TLR signaling pathways negatively regulate tumor inflammation remains unclear. In this report, we find that TLR4 signaling of H22 hepatocarcinoma tumor cells is transduced through MyD88 pathway to actin cytoskeletons, leading to the release of microparticles (MPs), the cellular memb...

Norcantharidin (NCTD), a demethylated form of cantharidin, has been used as a routine anticancer drug in China. In this study, the effect and mechanism of NCTD on anti-hepatocellular carcinoma (HCC) was examined. In vivo antitumor activity was investigated in hepatoma-bearing mice by intraperitoneal injection of different concentration of NCTD. The levels of MicroRNAs (miRNAs) and mRNA were det...

is the closure of the locus parametrizing H22-invariant quartics with 16 skew lines. The smooth surfaces of this type are parametrized by a non-empty open set N s of N . These surfaces are Kummer surfaces associated to abelian surfaces with a (1,3)–polarization. The action of the Heisenberg group on the Kummer surface corresponds to a level-2 structure on the abelian surface. If A is an abelian...

Aminopeptidase N(APN/CD13), a Zn2+-dependent ectopeptidase localized on the cell surface, is widely considered to influence invasion of tumor cells. We found that boroleucine and dino-leucine borate exhibited strong inhibitory effect enzyme activity aminopeptidase N. The tested assay indicated both compounds had an anti-proliferative triple-negative breast cancer Wound healing assay, migration ...