Introduction: According to evidence, Early-Life Stress (ELS), mood disorders, and medical comorbidities, i.e.  Irritable Bowel Syndrome (IBS), are correlated; however, the direct contribution of ELS to IBS manifestations is less understood. The current study aimed at evaluating the effect of voluntary exercise on the mitochondrial dysfunction of the bowel fibroblasts, following the confirmation...

Gut microbiota composition has been reported as a factor linking host metabolism with the development of cardiovascular diseases (CVD) and intestinal immunity. Such gut microbiota has been shown to aggravate CVD by contributing to the production of trimethylamine N-oxide (TMAO), which is a pro-atherogenic compound. Treg cells expressing the transcription factor Forkhead box protein P3 (FoxP3) p...

Background: Heavy metal containing wastes reaches to the food chain either directly or indirectly. These ingested toxic elements manifest direct impact on the gut ecosystem and its overall functioning. The present study explores the alteration in mice gut bacteria on exposure to mixture of toxic heavy metals through drinking water.  Methods: Twelve experimental groups of Swiss albino male and ...

I provide a short overview of the hypothesis of Yukawa unification within SUSY GUTs, emphasizing its motivations and its predictivity-enhancing role. I then discuss the status of the tests of this hypothesis, and the major role played by observables in the flavor sector. Concerning the patterns of soft SUSY-breaking terms assumed at the GUT scale, I focus on the cases of universalities on sferm...

The ability of the gut epithelium to defend against pathogens while tolerating harmless commensal organisms remains an important puzzle. In this issue of Cell Host & Microbe, Lee et al. (2015) reveal how pathogen-secreted uracil acts at two steps to induce ROS via the Hedgehog pathway.

background & aim: to assess functionality status and surgical outcome of fenestration versus laminotomy technique based on core outcome measures index (comi) in patients with lumbar disc hernia (ldh). methods & materials/patients: a cross-sectional study was performed between january 2007 and april 2012. a total of 108 patients with a single-level disc herniation were asked to respond to the os...