BACKGROUND Many healthcare interventions are of complex nature, consisting of several interacting components. Complex interventions are often described inadequately. A reporting guideline for complex interventions was published in 2012 (Criteria for Reporting the Development and Evaluation of Complex Interventions in healthcare, CReDECI) and was recently checked for its practicability. The repo...

BACKGROUND There is increasing concern that conflicts of interest affect the development process of clinical practice guidelines. We evaluated The American Psychiatric Association's Practice Guideline for the Treatment of Patients with Major Depressive Disorder to determine the existence of financial and intellectual conflicts of interest and examine their possible effects. We selected this gui...

Therapeutic Guideline Limited (TGL) is an Australian medical guideline publishing house. This paper discusses appropriate ways of using TGL content in a computer implemented guideline (CIG). Existing CIG representations are reviewed in light of TGL features such as the need for incremental development, strong existing relationship with guideline consumers, broad shallow guideline content, need ...

A rigorous development process of clinical practice guidelines through a systematic appraisal of available evidence is costly and time consuming. One way to reduce the costs and time, and avoid unnecessary duplication of effort of guideline development is by relying on a local adaptation approach of guidelines developed at the (inter)national level by expert groups. In this chapter we survey th...

BACKGROUND Developers, users and others have requested or advocated for guidance on how to plan for, and implement guidelines concurrent to their development given that existing resources are lacking such information. The purpose of this research was to develop a guideline implementation planning checklist. METHODS Documents that described or evaluated the processes of planning or undertaking...

background: granulocyte colony stimulating factors (gcsf) are high cost agents commonly recommended for primary and secondary prophylaxis of chemotherapy-induced neutropenia and febrile neutropenia. gcsfs have been shown to be beneficial in some patient subgroups, although they are probably overused in clinical settings. the american society of clinical oncology (asco) guidelines summarize curr...

UNLABELLED BACKGROUND All randomized clinical trials (RCTs) require a protocol; however, numerous studies have highlighted protocol deficiencies. Reporting guidelines may improve the content of research reports and, if developed using robust methods, may increase the utility of reports to stakeholders. The objective of this study was to systematically identify and review RCT protocol guideli...

BACKGROUND Core outcome sets can increase the efficiency and value of research and, as a result, there are an increasing number of studies looking to develop core outcome sets (COS). However, the credibility of a COS depends on both the use of sound methodology in its development and clear and transparent reporting of the processes adopted. To date there is no reporting guideline for reporting ...

BACKGROUND Clinical practice guidelines should be based on the best available evidence. However, this evidence is often incomplete, controversial, or lacking. Other considerations beyond the evidence are therefore needed to be able to formulate specific and applicable recommendations for clinical practice. OBJECTIVE The aim of this study is to obtain consensus among experts about a set of dom...

mangrove sediments were collected during wet and dry seasons from nine stations in khamir,laft and natural reservoir mangrove-dense areas of hormozgan province in the south of iran. σ pcbs ranged from 5.33 to 15.5 ng/g dry weight and the dominant congener was no.153. average σ ddts for khamir and laft mangroves were 16.58 ± 1.51 and 18.8 ± 9.98 ng/g dry weight. ddt was more abundant than dde an...