OBJECTIVE Successful repair of defects in the avascular zone of meniscus remains a challenge in orthopedics. This proof of concept study aimed to investigate a guided tissue regeneration approach for treatment of tears in meniscus avascular zone in a goat model. DESIGN Full-depth longitudinal tear was created in the avascular zone of the meniscus and sutured. In the two treatment groups, porc...

Dento-alveolar trauma and congenital absences are the most important causes of edentulism that are not associated with bacteria. However, the World Health Organization reports show that dental caries and periodontitis, two conditions of bacterial origin, are the most frequent oral diseases in humans [1]. These conditions might be avoided if an adequate oral preventive health policy is implement...

Grafts in the Peritoneal Cavity To the Editor: Tissue engineering represents an upcoming alternative source for vascular substitutes to create viable and biologically active grafts. Two different concepts are followed: grafts are either reseeded in vitro before implantation (tissue engineering)1 or the scaffolds are implanted as acellular matrices for intrinsic reseeding in vivo (guided tissue ...

BACKGROUND Conventional treatment of destructive periodontal (gum) disease arrests the disease but does not usually regain the bone support or connective tissue lost in the disease process. Guided tissue regeneration (GTR) is a surgical procedure that specifically aims to regenerate the periodontal tissues when the disease is advanced and could overcome some of the limitations of conventional t...

The objective of this investigation was to study the effectiveness of expanded polytetrafluoroethylene (e-PTFE) membranes for enhancement of bone ingrowth through subperiosteally implanted collagen/HA composite blocks. Twelve rabbits aged 12-15 months served as the experimental animals in this study. Two compressed Collagen/HA composite blocks in the shape of two attached cylinders of different...

the identification of multipotential mesenchymal stem cells (mscs) derived from adult human tissues such as bone marrow and connective tissues has provided exciting prospects for cell-based tissue engineering and regeneration. this review article focuses on the biology of mscs, their differentiation potentials in vitro and in vivo, and their application in tissue engineering. our current unders...

It has been recognized that a three-dimensional cell invasive scaffold that provides both topographical and chemical cues is desirable in regenerative tissue engineering to encourage cell attachment, migration, regrowth and ultimately tissue repair. Carbohydrate hydrogels are attractive for such applications because they are generally biocompatible and able to match the mechanical properties of...

The complexity of the tissues and the healing process of the periodontal wound turn the development of therapies for the predictable regeneration of functional periodontal tissues, a challenging exercise. In the last decades, the guided tissue regeneration (GTR) emerged as a strategy to drive the innate regenerative properties of the tissues involved in the periodontal apparatus (gingiva, tooth...