Pecan scab, caused by Venturia effusa, is the most economically damaging disease of pecan in southeastern United States, and annual epidemics are effectively managed through multiple fungicide applications. The applications can be single greatest operating cost for commercial growers return on that investment impacted resistance. V. effusa produces generations conidia per season, exhibits subst...

The solubility of human costal cartilage during exhaustive digestion with proteases (van der Korst, Sokoloff, and Miller, 1968) or 5 M guanidine-HCI (Miller, van der Korst, and Sokoloff, 1969) decreases with ageing. These observations stimulated us to investigate the quantitative effect of glycosaminoglycan and protein-degrading enzymes on costal cartilage in regard to age. The first enzyme stu...

We have carefully examined the frequency of guanidine-resistant revertants in six different clonal pools of guanidine-dependent mutants of type 1 poliovirus. The mutation frequency was (6.5 +/- 6.3) x 10(-4) (with all amino acid substitutions occurring at position 227). The minimal corrected base substitution frequency per single nucleotide site in the codon for amino acid 227 was (2.1 +/- 1.9)...

In the title compound, [Fe(C5H5)(C25H17Cl3N3O)], the isolated cyclo-penta-dienyl (Cp) ring is disordered over two set of sites in a 0.577 (8):0.423 (8) ratio. The dihedral angle between the other Cp ring and its attached benzene ring is 13.6 (3)°, and that between the benzene ring and the guanidine group is 64.8 (2)°. One of the N-H groups forms both an intra- and an inter-molecular N-H⋯O hydro...

With current anti-HIV treatments targeting only 4 of the 15 HIV proteins, many potential viral vulnerabilities remain unexploited. We report small-molecule inhibitors of the HIV-1 protein Nef. In addition to expanding the anti-HIV arsenal, small-molecule inhibitors against untargeted HIV proteins could be used to dissect key events in the HIV lifecycle. Numerous incompletely characterized inter...

BACKGROUND The history of the investigation of standardized mycobactericidal activity of disinfectants and antiseptics is not very long. There is growing interest among the manufacturers of disinfectants in carrying out research on the antimicrobial activities in accordance with European standards (EN). This research could facilitate the introduction of high-quality disinfectants to the market....

A novel and mild Rh(III)-catalyzed [5+1] oxidative cycloaddition between arylguanidines and alkynes efficiently affords C4-disubstituted 1,4-dihydroquinazolin-2-amines. Members of this family of heterocycles, which contain the relevant cyclic guanidine units, have shown interesting pharmacological properties. The mechanism probably involves the formation of an eight-membered rhodacycle in which...

The isolation and characterization of streptozotocin (STZ)-induced mutations in the phage P22 mnt repressor gene is described. Cells carrying the plasmid-borne mnt gene were exposed to STZ to give 10-20 percent survival and at least an eleven-fold increase in mutation frequency. DNA sequence analysis showed that 50 of 51 STZ-induced mutations were GC to AT transitions, and one was an AT to GC t...