نتایج جستجو برای: gsk3b
تعداد نتایج: 241 فیلتر نتایج به سال:
Many protein kinase (PK) inhibitors have been reported in recent years, but only a few have been approved for clinical use. The understanding of the available molecular information using computational tools is an alternative to contribute to this process. With this in mind, we studied the binding modes of 77 maleimide derivates inside the PK glycogen synthase kinase 3 beta (GSK3β) using docking...
Juvenile bipolar disorder (JBD) has been a subject of significant research and debate. Phenotypic differences between JBD and adult-onset bipolar disorder have led researchers to question whether or not similar neuropathologic mechanisms will be found. While much is known about the genetic and environmental contributions to the adult-onset phenotype, less is known about their contributions to J...
BACKGROUND The Long Life Family Study (LLFS) is an international study to identify the genetic components of various healthy aging phenotypes. We hypothesized that pedigree-specific rare variants at longevity-associated genes could have a similar functional impact on healthy phenotypes. METHODS We performed custom hybridization capture sequencing to identify the functional variants in 464 can...
Cannabis sativa L. (cannabis) is a medicinal plant and has been used for many years the treatment of epilepsy (EP), which common neurological disease. This study aimed to investigate mechanism cannabis action in EP, with emphasis on leading compounds, targets pathways. In this study, systematic pharmacology bioinformatics approaches were employed identify active ingredients potential treating E...
Bipolar disorder (BD) is a chronic and burdensome psychiatric disease, characterized by variations in mood energy. The literature has consistently demonstrated an association between BD childhood maltreatment (CM), genetic variants of circadian genes have been associated with increased vulnerability to develop BD. In this context, environmental factors such as CM may also contribute the suscept...
There is increasing evidence that p21(Cip1) and p27(Kip1) are requisite positive regulators of cyclin D1.CDK4 assembly and nuclear accumulation. Both Cip and Kip proteins can promote nuclear accumulation of cyclin D1, but the underlying mechanism has not been elucidated. We now provide evidence that p21(Cip1) promotes the nuclear accumulation of cyclin D1 complexes via inhibition of cyclin D1 n...
نمودار تعداد نتایج جستجو در هر سال
با کلیک روی نمودار نتایج را به سال انتشار فیلتر کنید