in this assay, the evaluation of lipophilicity of four ace-inhibitors and hydrochlorothiazide (hctz) with rp-tlc on cellulose layers was described using three binary solvent systems. the selected ace inhibitors had sufficiently different structures which can indicate the method suitability for their lipophilicity evaluation as the model substances in comparison with hctz. in addition, the linea...

objective diabetes mellitus is manifested by hyperglycaemia. different treatments such as diets and drugs are recommended for diabetes control. for various reasons in recent years traditional plant (herbal) therapies as prescribed by indigenous systems of medicine with different mechanisms have commonly been used. the digestive enzymes such as alpha glucosidase are among these herbal remedies. ...

background: factor viii administration to hemophilia a patients results in an immune response (inhibitor formation) which significantly complicates the therapy. the present study was performed to determine the prevalence of inhibitor development in hemophilia a patients receiving recombinant factor viii therapy. materials and methods: this was an observational descriptive study. clotting factor...

a series of structurally related 2,4-dioxopyrimidine-1-carboxamide derivatives as highly potent inhibitors against acid ceramidase were subjected to hologram quantitative structure-activity relationship (hqsar) analysis. a training set containing 24 compounds served to establish the hqsar model. the best hqsar model was generated using atoms, bond, connectivity, donor and acceptor as fragment d...

By analysing the growth kinetics of Dictyostelium discoideum amoebae in varying combinations of the components of the nutrient medium HL-5 (Cocucci & Sussman, 1970), we have demonstrated that Dictyostelium amoebae enter stationary phase when they deplete the medium of one or more nutrient components. However, if the medium of a stationary phase culture is supplemented with any of the initial co...

It has been known from the work of Maver and Dunn (.5) and others (a review of the earlier work is given in [5]) that the presence of certain tumors causes an increased catheptic activity in various host tissues. These observations have been con firmed and extended by Zamecnik and Stephenson (10, 11), who demonstrated that only certain of the catheptic enzymes were thus affected. The ef fect of...

Layered double hydroxide (LDH) single-layer nanosheets were traditionally prepared through a multi-step exfoliation process which is very time-consuming and of low efficiency. Herein we report the preparation of LDH single-layer nanosheets through a facile direct synthesis method. By introducing a layer growth inhibitor, one can directly synthesize LDH single-layer nanosheets instead of LDH lay...

A macroscopic model of the tumor Gompertzian growth is proposed. This approach is based on the energetic balance among the different cell activities, described by methods of statistical mechanics and related to the growth inhibitor factors. The model is successfully applied to the multicellular tumor spheroid data.

Fibroblast growth factors are key proteins in many intercellular signaling networks. They normally remain attached to the extracellular matrix, which confers on them a considerable stability. The unrestrained accumulation of fibroblast growth factors in the extracellular milieu, either due to uncontrolled synthesis or enzymatic release, contributes to the pathology of many diseases. Consequentl...

The comparative effects of metabolic inhibitors on acid- and auxininduced growth in oat (Avena sativa L. var. Victory) coleoptile segments have been examined. Acid (pH 4)-induced growth in both peeled and unpeeled segments is inhibited by 1 millimolar KCN when added at the time of acidification. KCN inhibits total acid-induced growth by 59 and 76%, respectively, in peeled and nonpeeled segments...