Using the heterotopically transplanted rat urinary bladder system, we previously showed that normal urine has a tumor-enhancing effect on carcinogen-initiated urothelium. In an attempt to isolate a urinary growth-stimulating (tumor-enhancing) factor(s), urine was first fractionated by Bio-Gel P-100 column chromatography, and each fraction was tested for inducibility of ornithine decarboxylase (...

The effects of 17 beta-estradiol and tamoxifen (TAM) on the proliferation of responsive MCF-7 and unresponsive HBC-4 human breast cancer cells were studied in a defined culture medium containing insulin (2 micrograms/ml), transferrin (2 micrograms/ml), ethanolamine (2 microM), and selenite (25 nM). MCF-7 cells grew at a population-doubling rate of 2.0 days in serum-free medium and at a rate of ...

The characteristic limited reproductive life-span of normal human fibroblasts in culture is due to a steadily decreasing fraction of cells able to proliferate in the standard rich growth media. We have observed that restricting the growth factor supply to old cells for variable lengths of time in culture increases the fraction of cells that can enter S-phase; although these cells do not go on t...

We present an experimental study of the terahertz emission from InxGa1−xAs epitaxial layers that were grown while varying alloy fraction x. observe is significantly different depending on variation direction fraction. attribute difference to significant change band bending induced in growth and position-dependent effective mass.

Natural killer (NK) cells are directly cytotoxic for tumor cells and play a primary role in regulating immune responses. We monitored levels of NK cell cytotoxic activity in cancer patients receiving D-Fraction extracted from maitake mushrooms (Grifola frondosa). Elevated levels of cytotoxic activity were maintained for one year. To elucidate the mechanisms underlying long-term activation of NK...

OBJECTIVES The adrenal cortex produces aldosterone, cortisol and androgens in response to ACTH and angiotensin II. To define the differential response of morphologically distinct cells of the adrenal cortex, we examined the phenotypical and functional characteristics of human adrenocortical cells. RESULTS Tumour growth factor-beta receptor-1 (TGFbeta-R1) and CYP-11 were found to be expressed ...

the influence of salinity on the different polyamine fractions (free, conjugated, and bound) was compared in a natrophilic halophyte (beta vulgaris l. cv. ic) and a salt sensitive glycophyte (nicotiana rustica l. cv. basmas). low-level salinity (25 mm nacl) and high salinity (150 and 50 mm nacl for sugar beet and tobacco, respectively) were supplied in hydroponics. under low salinity shoot dry ...