The orbital parameters of the recently discovered transient burster/pulsar GRO J1744–28 indicate that this system is a low-mass X-ray binary in an advanced stage of its mass transfer, with several tenths of a solar mass already transferred from the donor to the compact star. All neutron stars known to have accreted such an amount have very weak magnetic fields, and this has led to the idea that...

Chemokines are chemotactic cytokines involved in leucocyte trafficking to infected tissue. Growth-related oncogene (GRO) chemokines namely CXCL1, CXCL2 and CXCL3 are neutrophil activating chemokines sharing a conserved three-dimensional structure, but encompassing functional diversity due to gene duplication and evolutionary events. However, the evolutionary mechanisms including selection press...

BACKGROUND In addition to lowering cholesterol, statins are thought to beneficially modulate inflammation. Several chemokines including CXCL1/growth-related oncogene (GRO)-α, CXCL8/interleukin (IL)-8 and CCL2/monocyte chemoattractant protein (MCP)-1 are important in the pathogenesis of atherosclerosis and can be influenced by statin-treatment. Recently, we observed that atorvastatin-treatment a...

Streptococcus agalactiae (group B Streptococcus [GBS]) remains a leading cause of invasive infections in neonates and has emerged as a pathogen of the immunocompromised and elderly populations. The virulence mechanisms of GBS are relatively understudied and are still poorly understood. Previous evidence indicated that the GBS cspA gene is necessary for full virulence and the cleavage of fibrino...

The proinflammatory CXC chemokines GRO, CINC-2alpha, and macrophage inflammatory protein (MIP)-2 are a closely related family of neutrophil chemoattractants. Here, we report that freshly isolated alveolar Type II (TII) cells express these chemokine mRNAs at much higher levels than do freshly isolated Type I cells or alveolar macrophages (AM). TII cells also express CXCR2, the receptor for these...

INTRODUCTION Transcriptional repressors commonly recruit accessory proteins known as co-repressors (CoRs) that provide them with repressive activity by modifying chromatin structure. CoRs, such as Groucho (Gro) and C-terminal binding protein (CtBP), function as part of complexes containing enzymes that influence transcription by covalently modifying histones and influencing nucleosome packing a...

The mammalian AML/CBFalpha runt domain (RD) transcription factors regulate hematopoiesis and osteoblast differentiation. Like their Drosophila counterparts, most mammalian RD proteins terminate in a common pentapeptide, VWRPY, which serves to recruit the corepressor Groucho (Gro). Using a yeast two-hybrid assay, in vitro association and pull-down experiments, we demonstrate that Gro and its mam...

Interest in graphene, which is a new material, increasing day by due to its unique mechanical, electrical, and thermal properties. Graphite oxide (GRO), synthesized as result of series chemical processes graphite, was used the primary material production graphene film. In this study, firstly, (GO) dispersions with different exfoliation degrees were prepared from de-ionized water (DI-water) repe...

Glavonoid-rich oil (GRO) derived from ethanol extraction of licorice (Glycyrrhiza glabra Linne) root has been reported to have beneficial effects on health. In this study, we aimed determine the effect long-term administration GRO metabolic disorders and elucidate molecular mechanism. Female obese, type 2 diabetic KK-Ay mice were fed diets supplemented with 0.3% or 0.8% (w/w) for 4–12 weeks. Mi...