Growth of a transplantable mammary cancer in CE mice (CE 1460 MA CA) was paralleled by hyperplasia of the granulocytic elements of the bone marrow and peripheral leukocytosis (up to 350,000 leukocytes/cu mm) with a lymphoid-myeloid ratio re versal to 1:4 and a shift to the left. About 5-20% of the granulo cytic elements in the blood and bone marrow showed morpho logic abnormalities. Hematocrit ...

A neutropenic child of 20 months suffered generalized infection with Pseudomonas aeruginosa, involving the bloodstream and the meninges. This was successfully treated with intravenous and intrathecal antibiotics and granulocyte transfusions before granulopoiesis recovered spontaneously. No immunoglobulin replacement was given during the acute episode, as the diagnosis of X-linked hypogammaglobu...

Multicytokine therapy may be useful to counteract radiation-induced myelosuppression. We assessed the stem cell factor + glycosylated erythropoietin + pegylated granulocyte colony-stimulating factor combination (SEG) as an emergency treatment. SEG in highly irradiated monkeys efficacy appeared to be restricted to granulopoiesis. Early administration of Erythropoietin did not prevent radiation-i...

A neutropenic child of 20 months suffered generalized infection with Pseudomonas aeruginosa, involving the bloodstream and the meninges. This was successfully treated with intravenous and intrathecal antibiotics and granulocyte transfusions before granulopoiesis recovered spontaneously. No immunoglobulin replacement was given during the acute episode, as the diagnosis of X-linked hypogammaglobu...

In this paper the development of a simulation environment for time delay differential equations will be presented. After the analysis of the mathematical foundations, the practical implementation using the C++ programming language will be discussed. Simulations of a biomathematical time delay model of the human granulopoiesis are presented and the paper concludes with an error analysis and a di...

Lactoferrin (LF), the iron-binding protein present in the specific granules of mature granulocytes has been identified as colony inhibitory factor (CIF) which suppresses granulocyte--macrophage colony stimulating activity (CSA) production by monocytes and macrophages in vitro and rebound granulopoiesis in vivo. Separation of LF and CIF by isoelectric focusing confirmed that the regions of inhib...

Growth of a transplantable mammary cancer in CE mice (CE 1460 MA CA) was paralleled by hyperplasia of the granulocytic elements of the bone marrow and peripheral leukocytosis (up to 350,000 leukocytes/cu mm) with a lymphoid-myeloid ratio re versal to 1:4 and a shift to the left. About 5-20% of the granulo cytic elements in the blood and bone marrow showed morpho logic abnormalities. Hematocrit ...

I T IS NOW WELL ESTABLIShED that erythropoiesis is actively regulated in response to demand’ and evidence is accumulating that thrombopoiesis is ew2 A Priori reasoning and analogy suggest that granulopoiesis also is actively regulated but evidence to support this is scant. Reports by several groups of workers suggest that depletion of circulating neutrophils by means of leucapheresist or inject...

The evidence for a regulatory role of acidic isoferritins on hemopoiesis is not entirely consistent with our knowledge of ferritin biochemistry, and no clear picture of this phenomeonon has emerged. In the present study, we have been unable to confirm a consistent effect of purified heart (acidic), spleen (basic), or serum (glycosylated) isoferritins on CFU-GM colony formation in vitro. Inhibit...