background: over the past decade, survival from advanced colorectal cancer is increasing. therefore patients have more exposure to chemotherapy and related toxicities. this study determines how hematologic toxicity patterns affect therapy and care. methods: from april 2010 to march 2013, we enrolled 127 patients with stages iib to iv colorectal cancer. patients underwent complete blood count mo...

we present a 24-year-old female referred with non-healing wound of a few days duration on anterior aspect of her right foreleg. biopsy of the wound was reported to be pyoderma gangrenosum on pathologic report. further work up of the patient for high grade fever and occasional leukopenias revealed the diagnosis of cyclic neutropenia. treatment with granulocyte colony-stimulating factor (g-csf) r...

17. Morstyn G, Campbell L, Lieschke G, et al. Treatment of chemotherapy induced neutropenia by subcutaneously administered granulocyte colony-stimulating factor with optimization of dose and durationof therapy.3 Clin Oncoll989,7,1554-1562. Brugger W, Bross KJ, Lindemann A, Kanz L, Mertelsmann M. Role of hematopoietic growth factor combinations in experimental and clinical oncology. Semin Oncoll...

Study of growth factor RNA levels in the stromal cells derived from the adherent layer of long-term bone marrow culture demonstrated constitutive expression of transforming growth factor beta 1 (TGF-beta 1) and macrophage colony-stimulating factor. These cells did not express granulocyte colony-stimulating factor, granulocyte-monocyte colony-stimulating factor, interleukin (IL) 1 alpha, IL-1 be...