In the last decade, gene expression studies of kidney transplants provided an opportunity to better understand the development and regulation of kidney graft rejection. This review outlines the progress in the definition of biomarkers of rejection and, above all, concentrates on studies of the molecular phenotype of rejection. This phenotype, rather than morphological characterization, may be c...

PURPOSE Immunologic rejection is the most common cause of corneal allograft rejection. Ipsilateral ocular inflammation has been identified as a predictor of future corneal graft failure. This study investigates the effect of perioperative allergic conjunctivitis on corneal allograft survival. METHODS C57BL6 donor corneas were transplanted into naive A/J mice, A/J mice sensitized to short ragw...

HYPOTHESIS We hypothesized that improved outcomes following renal transplantation in high-risk infants and small children primarily are due to advances in immunosuppression and accurate diagnosis of rejection. Optimizing renal allograft perfusion is critical to achieving good early graft function and decreasing early graft loss. DESIGN Twenty-eight consecutive recipients (weighing <20 kg) of ...

Allogeneic bone marrow transplantation (BMT)' has become a major therapeutic modality in the treatment of various malignant and nonmalignant hematologic disorders (1-6) . However, graft-vs.-host disease (GuHD) causes much morbidity and mortality after transplantation (7, 8) . Since GvHD is mediated by immunocompetent T cells in the graft (9, 10), depletion of T cells from the bone marrow graft ...

Small bowel transplantation is a life-saving surgery for patients with intestinal failure. The biggest problem in intestinal transplantation is graft rejection. Graft rejection is the main reason for morbidity and mortality. Rejection has a negative effect on the survival of the graft. While 50%-75% of small bowel transplantation patients experience acute rejection, chronic rejection occurs in ...

Despite recent improvements in immunosuppressive therapy, hepatic allograft rejection remains a major cause of morbidity and late graft loss in patients undergoing liver transplantation. Although some biochemical tests suggest hepatic allograft damage, the gold standard for defining rejection remains based on morphologic findings. Acute cellular rejection usually occurs within the first 3 weeks...

In the last decade, gene expression studies of kidney transplants provided an opportunity to better understand the development and regulation of kidney graft rejection. This review outlines the progress in the definition of biomarkers of rejection and, above all, concentrates on studies of the molecular phenotype of rejection. This phenotype, rather than morphological characterization, may be c...

BACKGROUND Patients with end stage renal disease (ESRD) can be sustained with dialysis therapy. OBJECTIVES In this study, we followed up the effect of early acute and late acute rejections on survival rates of patients' grafts. PATIENTS AND METHODS We investigated the timing and frequency of acute rejection episodes related to long-term patient-graft survival in Taleghani hospital between 1...

The object is analysis of the impact of acute and chronic rejection on long-term function in HLA-identical renal transplants performed from 1967 to 1995 by the Saskatchewan Renal Transplant Unit. Forty-eight grafts in 46 patients were studied, of which 39 were first and nine second grafts. Forty-two were for primary and six for secondary renal disease. Thirty-five received azathioprine/predniso...

OBJECTIVES Delayed graft function affects up to 50% of kidney transplant recipients. Some guidelines recommend surveillance biopsies beginning 7 days after engraftment. This may be unnecessary with anti-thymocyte globulin induction. MATERIALS AND METHODS We conducted a retrospective study of deceased-donor renal transplant recipients with delayed graft function. RESULTS One hundred eleven p...