Early studies considered that fibrinogen receptor (glycoprotein [GP] IIb–IIIa or platelet integrin aIIbb3) is the binding site for low-density lipoprotein (LDL) and high-density lipoprotein type 3 (HDL3). Recent data, however, do not support the hypothesis that the binding of LDL to human intact resting platelets is related to integrin aIIbb3. In this study we present evidence that platelet int...

BACKGROUND The PlA2 polymorphism of glycoprotein IIIa (GPIIIa) has been previously identified as being associated with myocardial infarction (MI), but whether this represents a true association is entirely unclear due to differences in findings from different studies. We performed a meta-analysis to evaluate whether this polymorphism is a risk factor for MI. METHODS Electronic databases (MEDL...

Glycoprotein IIIa (GPIIIa) has a key role in the aggregation of thrombocytes, and it also mediates intimal hyperplasia after endothelial injuries; the possible association of the Pl polymorphism of the gene for GPIIIa with coronary thrombosis and with the progression of coronary artery disease (CAD) is still to be confirmed. Therefore, the association of the Pl polymorphism with the development...

BACKGROUND AND PURPOSE Few genetic modifications have been identified to be associated with subarachnoid hemorrhage (SAH), most of them playing a role in the formation or size of aneurysms. METHODS We evaluated the role of common and functional polymorphisms affecting the main platelet adhesive glycoproteins (GP) (GPIIIa: HPA-1; GPIa: HPA-5 and C807T; GPIbalpha: HPA-2 and VNTR) in the risk fo...

Platelet hyperaggregation in ischaemic stroke patients is a proven finding, and associated with increased expression of the platelet surface GPIIb/IIIa receptor. The polymorphism occurs at nucleotide position 1565 of the GPIIIa gene resulting a 33Leu-Pro change. Data are conflicting regarding the abnormal function of the PlA1/A2 receptor in stroke. The aim of the study was to address the differ...