The brush border of small intestinal enterocytes is highly enriched in cholesterol- and glycosphingolipid-containing membrane microdomains, commonly termed as lipid 'rafts'. Functionally, transcytosis of IgA and exocytosis of newly made brush-border proteins in enterocytes occur through apical lipid raft-containing compartments, but little is otherwise known about these raft microdomains. We th...

To develop our understanding of myosin-1a function in vivo, we have created a mouse line null for the myosin-1a gene. Myosin-1a knockout mice demonstrate no overt phenotypes at the whole animal level but exhibit significant perturbations and signs of stress at the cellular level. Among these are defects in microvillar membrane morphology, distinct changes in brush-border organization, loss of n...

Figure 1: Calligraphy made with our system This paper presents a novel 3D brush model consisting of a skeleton and a surface, which is deformed through constrained energy minimization. The main advantage of our model over existing ones is in its ability to mimic brush flattening and bristle spreading due to brush bending and lateral friction exerted by the paper surface during the painting proc...

This paper reports the development of a lead-free brush material for high-load starter motors. These brushes can be used in much more extreme conditions --at a PV-value (the product of the brush contact pressure and sliding velocity) approximately three times that of conventional starter motor brushes, and double the electrical current density. The major technical requirement for this developme...

We propose the design of a novel mixed polymer brush system that could act as a selective sensor with a distinct on-off switch. In the proposed system, a (single) nanoparticle (such as an antibody) is end-attached to a responsive chain, which is surrounded by a brush of nonresponsive chains. The collapse of the responsive chain leads to a protected state, where the nanoparticle is hidden in the...

We present the results of discontinuous molecular dynamics simulations of mechanically assembled monolayers in good solvent. Polymers of chain lengths 5-100 were end-grafted to surfaces at low density and then compressed laterally at varying rates. Data for brush thickness and end-monomer density were collected as a function of surface density; they were shown to correspond well with theoretica...

This paper proposes a novel algorithmic framework for an advanced virtual brush to be used in interactive digital painting. The framework comprises the following components: a geometry model of the brush using a hierarchical representation that leads to substantial savings in every step of the painting process; fast online brush motion simulation assisted by offline calibration that guarantees ...

iron oxide, [ 10 ] zinc oxide, [ 11 ] cadmium selenide, [ 12 ] gold [ 13 ] and others in nanocomposites is a promising approach to introduce new functionalities to a polymer such as tunable refractive index, magnetism, surface hardness, UV absorption, etc. However, aggregation of nanoparticles is commonly encountered, leading to unsatisfactory performance of nanocomposites and frustrating effor...

Morphological transformations in polymer brushes in a binary mixture of good and bad solvents are studied using dissipative particle dynamics simulations drawing on a characteristic example of polyisoprene natural rubber in an acetone-benzene mixture. A coarse-grained DPD model of this system is built based on the experimental data in the literature. We focus on the transformation of dense, col...