During the past decade there have been remarkable achievements in the immunopathogenesis of the inflammatory myopathies that laid the grounds for more eVective therapeutic interventions. This editorial summarises where we stand today in our understanding of these disorders and their treatment, identifies key biological issues that need further study, and considers possibilities of applying new ...

This is really the overarching question associated with model calibration: are the models good enough? But the question has to be asked in the framework of what the models will be asked to do, which is to evaluate remedial alternatives. (Problem identification is usually the first step in model evaluation; see, e.g., Ditmars et al., 1987.) The following sketch and discussion provide a framework...

Attachment theory is presented in this article as involving embodied relational processes within complex relational systems. Two narrative-like ‘events’ are re-presented to illustrate very young children playfully relating – connecting and communicating interand intrasubjectively. The ethnographic-inspired research methods included the researcher as a participant observer, an outsider, an other...

A numerical technique is presented which yields an exact solution to the one-dimensional scattering problem. The algorithm is used to compute phase shift error curves associated with the WKB approximation. A variety of scattering potentials are considered and cover cases for which the WKB solution varies from extremely good to poor. It is shown that some commonly assumed forms for ionospheric e...

provided x is sufficiently large. An asymptotic formula of type (1) Df (x; q, a) = (1 +O((log x)))Df (x; q) , in which the error term is smaller than the main term by a suitable power of log x, is good enough for basic applications. More important than the size of the error term is the range where (1) holds uniformly with respect to the modulus q. In this paper we consider the problem for the d...

In this paper, we present some guidelines for implementing various financial instruments for the purposes of credit and payment, including protocols for commercial transactions, dispute resolution, and establishing credit reputation. We strive to employ only widely used, standardized cryptography and keep the proposed procedures as simple as possible on the conceptual level. Also, we want all t...

Ende März 2001, just während der Tage, in denen sich die IT-Welt zur CeBIT in Hannover traf, machte die Nachricht über eine Attacke auf das verbreitete Verschlüsselungsprogramm PGP Schlagzeilen. Die Computerzeitschrift c’t stellte sogar vorübergehend die alljährlich angebotene Zertifizierung von PGP-Schlüsseln auf ihrem Messestand ein. Glücklicherweise erwiesen sich nach ersten Analysen der kur...

The dilution of academic standards and poor quality publications have become a global concern. Recently, in an editorial of Current Science, SC Lakhotia, an eminent scientist from Banaras Hindu University (BHU) has raised a very important issue regarding predatory journals and academic pollution. This problem is presently worrying almost every conscientious academician. [1] Substantial efforts ...

The relative status of women is poor in the developing world, compared to developed countries. Increases in per capita income lead to improvements in different measures of gender equality, suggesting that there may be market failures hindering investment in girls in developing countries, and that these are typically overcome as development proceeds. Gender inequality in education and health can...

this paper considers the economic lot scheduling problem, that is, the problem of scheduling several products on a single facility so as to minimize holding and setup costs. combination of frequency and timing as well as production quantity make this problem np-hard. a heuristic is developed to obtain a good solution to elsp. the proposed heuristic makes use of the simulated annealing technique...